Background: Possible relationship between dermatoglyphic patterns and other diseases, including dermatological diseases, especially those with genetic and hereditary basis such as vitiligo, psoriasis, alopecia areata, have been found in various studies but there is paucity of data from India to uphold the association. Aims and Objectives: To study the relationship between dermatoglyphic patterns with various dermatoses such as psoriasis, vitiligo, alopecia areata, and pemphigus vulgaris. Material and methods: This hospital based study involved 140 patients with psoriasis, 76 with vitiligo, 84 with alopecia areata and 30 pemphigus vulgaris patients, compared to 1838 age and sex matched control patients. Rolled finger and hand prints of palmar surfaces of both hands were obtained by the ink method. Results and observations: In the control group, loop pattern of dermatoglyphics was the commonest, found in 54.52%, followed by whorls in 36.78% and arch in 8.70%. In psoriasis patients, whorl pattern was the commonest (44.29%), followed by 31.43% loop, 21.43% arch and 2.86% composite pattern. In vitiligo patients, loop and whorl pattern was found in 44.74% patients each, followed by arch pattern in 10.53%. In patients of alopecia areata, whorl pattern was found in 45.24% patients followed by loop in 30.95% and arch pattern in 23.81% while in pemphigus vulgaris patients, loop pattern was found in 50% patients, followed by whorl in 40% and arch in 10% patients. Conclusion: There was statistically significant difference between psoriasis patients and controls regarding loop, arch and composite patterns, but no significant difference with respect to whorl pattern. Similarly, there was a significant difference between alopecia areata patients and controls for loop and arch patterns, but no significant difference regarding whorl pattern. There was, however, no
The data observed in the present study confirm that the saffron dermatitis is a distinct clinical entity with characteristic clinical presentation and has a strong significance as an occupational allergen in those handling this plant. Patch testing with different parts of saffron flower has a role to play in finding out the etiological cause.
Introduction:The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, Dryness due to EGFR inhibition) syndrome is a cutaneous adverse effect of EGFR inhibitors. Case report: We describe an 80-year-old man, who presented with itchy papules over the suprapubic region and hair growth over the lower back for 1 month. He was diagnosed with squamous cell carcinoma of the lung, and was treated with oral gefitinib 250 mg daily for 4 months. Cutaneous examination revealed generalized xerosis, discrete papules and pustules with overlying yellow crusts over the suprapubic region, and paronychia with dystrophic changes over the right first and third toe nail. Localised hypertrichosis was seen over the back in midline lumbosacral region. Conclusions: Hair overgrowth such as trichomegaly and hypertrichosis have been described in the PRIDE syndrome. We describe an atypical presentation of the syndrome with lumbosacral hypertrichosis.
Background: Complementary and alternative medicine is very robust in some parts of the world. The study was done to impart the experiential learning related to sources of drugs in a pharmacy practical class for MBBS students.Methods: We used ingredient-tray (I-Tray) teaching tool consisting of two parts to generate experiential learning in MBBS students about ethno pharmacological sources of drugs. Innovatively designed I -tray filled with two sizes plastic containers (100 ml and 50 ml sizes used for collecting biological samples of sputum and urine) containing crude drug medicinal sources which were arranged in gutters of the tray. They were sorted into five categories such as plants (flowers of Vinca rosea, bark of Terminalia arjuna, roots of Rauwolfia serpentine and Eucalyptus leaves); animals (formalin preservatives freshwater leech, shells and vaccines); minerals (kaolin, potassium permanganate and charcoal); oils and others. Three charts of 4 square feet sizes were used for demonstration of synthetic, microbiological and genetically engineered drug sources.Results: The students’ approval rate of I-tray was mean yes value of 105.78 for a tool of active learning out of total 113 students. Around 100%, 98.23 % and 97.35% students utilised application of concept (cognition), faculty of smell (affective) and volunteering (psychomotor) in the class. However female students had statistically significant score against this set up of the class depicting gender specificity of the learning process.Conclusions: Thus teaching traditional sources of drugs through I-tray impart higher order social, place based and experiential learning of medicine.
Today the world is dealing with rapidly increasing cases of diabetes mellitus especially type 2 diabetes which creates insulin resistance. Scientists are working with different nutraceuticals to cure this disease. Objective: Ginger plays an important role in different ailments such as cardiovascular diseases, hypertension, cancers, gastrointestinal functions, and diabetes mellitus. In the present study, ginger powder was analyzed for its anti-diabetic effect. The ginger powder was analyzed for its proximate composition. Methods: The bio-efficacy study was done on Alloxan-induced Wistar rats by feeding them ginger powder at three levels i.e. 1%, 3%, and 5% ginger powder for a period of 4 weeks. There were 4 groups (one was control and the other three getting different percentages of ginger powder), each containing 5 rats. The blood samples were collected at 0 days, 15th day, and 28th day. Blood sugar and insulin levels were measured. The data thus obtained was statistically analyzed to find out the level of significance. Results showed that glucose levels significantly decreased along with a significant increase in insulin levels. This research design concludes that ginger powder has positive effects in lowering blood sugar levels. Hence, the usage of ginger powder and ginger tea should be increased in diabetic patients to reduce hyperglycemia in diabetic patients and overcome high BSL levels in pre-diabetics. Conclusions: Results of this study concluded that in ginger powder 1.7 STD magnesium and 0.3 STD chromium are present. Moreover, this research study also declared that mean values of RFTs i.e. bilirubin, creatinine, urea, uric acid had a significant change in the G4 group as mean results of 0.591±0.032, 0.814±0.058, 0.814±0.058, 0.9508±0.051 respectively.
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