PRIDE syndrome with lumbosacral hypertrichosis

Abstract

Introduction:The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, Dryness due to EGFR inhibition) syndrome is a cutaneous adverse effect of EGFR inhibitors. Case report: We describe an 80-year-old man, who presented with itchy papules over the suprapubic region and hair growth over the lower back for 1 month. He was diagnosed with squamous cell carcinoma of the lung, and was treated with oral gefitinib 250 mg daily for 4 months. Cutaneous examination revealed generalized xerosis, discrete papules and pustules with overlying yellow crusts over the suprapubic region, and paronychia with dystrophic changes over the right first and third toe nail. Localised hypertrichosis was seen over the back in midline lumbosacral region. Conclusions: Hair overgrowth such as trichomegaly and hypertrichosis have been described in the PRIDE syndrome. We describe an atypical presentation of the syndrome with lumbosacral hypertrichosis.