Objective: The aim of the study is to correlate the AST to platelets ratio (APRI) with different stages of liver fibrosis measured by the fibroscan. Methods: The study included 40 patients. The study was conducted in outpatient clinic of Lahore General Hospital. The study duration was from November-2020 to January-2021. Their fibroscan data was collected from hepatic clinic of general hospital OPD and their AST and Platelets values were obtained retrogradely from the PACS system of hospital. Correlation between the APRI and fibroscan values was done by linear Pearson correlation test. Results: APRI values showed moderately positive correlation with increased kpa values and different stages of fibrosis (r=0.55). Similarly, the correlation coefficient of AST also shown to be moderately positive correlated with kpa values and stages of fibrosis however this correlation was slightly weak as compared to APRI values (r=0.49). The correlation coefficient (r) for platelets showed moderately negative correlation with liver fibrosis stages (r=-0.43). Conclusions: APRI levels increased as the degree of fibrosis and inflammation increased in patients suffering from chronic hep B and hep C. So, our data showed the clinical significance of APRI levels in diagnosing extent of liver fibrosis and cirrhosis. Keywords: AST, Platelets, APRI, fibroscan, chronic hepatitis
Background: Diagnosis of spinal tuberculosis is a major challenge. It is usually made using a blend of, laboratory , imaging investigations, clinical and none of these are 100% confirmatory. The objective of this study was to determine the diagnostic accuracy of magnetic resonance imaging (MRI) for detection of spinal tuberculosis (TB) Methodology: This cross-sectional study was conducted in the department of Radiology, Lahore General Hospital, on 150 patients, with suspicion of spinal TB from January,2020 to August,2020. Patients having Backache for >6 months, loss of appetite, loss of weight >10% in previous one month, raised ESR >15 mm/hour, and positive sputum results for AFB were included. The patients underwent full spinal MRI scan. MRI was done using 1.5 Tesla MR for diagnosis of spinal TB. The diagnosis of spinal TB was then confirmed on histopathologic reporting. Results:Mean age of study participants was 47.83±9.65 years. There was male predominance with 93 (62.0%) males and 57 (38.0%) female patients. The mean duration of spinal TB symptoms was 11.52±3.12 months. On accuracy of MRI, there were 83 (55.3%) true positive cases, 10 (6.67%) false positive, 08 (5.33%) false negative and 49 (32.67%) true negative. The sensitivity of MRI was 91.2%, specificity 83.1%, positive predictive value (PPV) 89.2% and negative predictive value (NPV) 86.0%. Conclusion: Sensitivity of MRI was 91.2% and specificity 83.1%.MRI is an ideal non-invasive imaging modality for the diagnosis of spinal TB. Keywords: Magnetic resonance imaging, Spinal, Tuberculosis.
Background: The purpose of the study is to evaluate the diagnostic value of DWI and MRS in assessment of the malignant brain lesions. Materials and methods: The study was conducted in Department of Diagnostic Radiology from March 2021, to December 2021 in Lahore General Hospital. Sample size selected was 50 patients referred to the Department of Diagnostic Radiology for their suspected brain lesion assessments. The patients were evaluated by the DWI magnetic resonance imaging and MRS. Classifications of lesions were benign and malignant on the basis of radiological findings. The data was compared with the histopathological results as a gold standard. Results: The malignant lesions from benign lesions were differentiated with DWI images and ADC mapping. Lower ADC values with restricted diffusion was considered malignant and higher ADC value with no restricted diffusion was considered benign. DWI images findings had the 77% sensitivity and 75% specificity. Cho/Cr, Cho/ NAA ratios has highest sensitivity and specificity at short TE (96%,86%) Conclusion: DWI and MRS are helpful noninvasive techniques in detecting the malignant brain lesions and can help to avoid unnecessary biopsy in the patients suspecting brain lesions. Keywords: Brain lesion, Diffusion weighted image, Malignant, Benign, MRS
Objective: To determine the diagnostic accuracy of BIRADS in diagnosing malignant breast lesions in patients with palpable breast lump. Patients and Methods: A total number of 100 patients presenting with Palpable breast lump were included in this study. The study was conducted in radiology unit of Lahore General Hospital Lahore from August-2021 to April-2022. Data regarding baseline study variables such as age, living area and socioeconomic status was collected for each patient. Ultrasound examination of the breast masses was done by an expert radiologist for calculation of BI-RADS score. Diagnosis of malignancy on histopathological findings was also made. Results: Mean age of patients was 41.04±11.00 years. There were 43 (43.0%) from rural areas and 57 (57%) from urban areas. Malignancy on BI-RADS was found in 42 (42%) patients. On evaluation of diagnostic accuracy of BI-RADS, BI-RADS was 92.5.0% sensitive, 88.3% specific having 84.1% PPV and 94.6% NPV (Table 1). Conclusion: When compared to histopathologic diagnosis, the findings of our study demonstrated that BIRADS is an accurate and trustworthy method for diagnosing breast lumps. Key Words: Palpable breast lump, BI-RADs Scoring, Histopathology.
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