Abstract-A rapidly emerging trend in the IT landscape is the uptake of large-scale datacenters moving storage and data processing to providers located far away from the end-users or locally deployed servers. For these large-scale datacenters power efficiency is a key metric, with the PUE (Power Usage Effectiveness) and DCiE (Data Centre infrastructure Efficiency) being important examples. This paper proposes a belief rule based expert system to predict datacenter PUE under uncertainty. The system has been evaluated using real-world data from a data center in the UK. The results would help planning construction of new datacenters and the redesign of existing datacenters making them more power efficient leading to a more sustainable computing environment. In addition, an optimal learning model for the BRBES demonstrated which has been compared with ANN and Genetic Algorithm; and the results are promising.

Acute coronary syndrome (ACS) is responsible for the obstruction of coronary arteries, resulting in the loss of lives. The onset of ACS can be determined by looking at the various signs and symptoms of a patient. However, the accuracy of ACS determination is often put into question since there exist different types of uncertainties with the signs and symptoms. Belief rule-based expert systems (BRBESs) are widely used to capture uncertain knowledge and to accomplish the task of reasoning under uncertainty by employing belief rule base and evidential reasoning. This article presents the process of developing a BRBES to determine ACS predictability. The BRBES has been validated against the data of 250 patients suffering from chest pain. It is noticed that the outputs created from the BRBES are more dependable than that of the opinion of cardiologists as well as other two expert system tools, namely artificial neural networks and support vector machine. Hence, it can be argued that the BRBES is capable of playing an important role in decision making as well as in avoiding costly laboratory investigations. A procedure to train the system, allowing its enhancement of performance, is also presented.

With the advances of liquid biopsy technology, there is increasing evidence that body fluid such as blood, urine, and saliva could harbor the potential biomarkers associated with tumor origin. Traditional correlation analysis methods are no longer sufficient to capture the high-resolution complex relationships between biomarkers and cancer subtype heterogeneity. To address the challenge, researchers proposed machine learning techniques with liquid biopsy data to explore the essence of tumor origin together. In this survey, we review the machine learning protocols and provide corresponding code demos for the approaches mentioned. We discuss algorithmic principles and frameworks extensively developed to reveal cancer mechanisms and consider the future prospects in biomarker exploration and cancer diagnostics.

A Clinical Decision Support System (CDSS) to assess suspicion of a disease would avoid unnecessary cost of medical diagnosis. Heart Failure (HF) is a complex clinical syndrome of cardiac disorder. In the present paper, a Belief rule based (BRB) CDSS has been proposed to assess suspicion of HF by using signs, symptoms and risk factors. The recently developed generic rulebased inference methodology using the evidential reasoning approach (RIMER) was considered as the methodology for developing this CDSS. Netbean7.2's GUI and MySQL server have been employed to develop the system. This belief rule based CDSS can deal with various types of uncertainties found in clinical sings, symptoms, risk factors and domain knowledge. The knowledge based for this system has been developed by taking account of real patient data, obtained in consultation with specialists. The CDSS has been tested by using the data taken from the patients with breathlessness. It has been observed that the results generated by the system is reliable and thus facilitates to take decision to avoid unnecessary costly medical diagnosis.

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Motivation The early detection of cancer through accessible blood tests can foster early patient interventions. Although there are developments in cancer detection from cell-free DNA (cfDNA), its accuracy remains speculative. Given its central importance with broad impacts, we aspire to address the challenge. Methods A bagging Ensemble Meta Classifier (CancerEMC) is proposed for early cancer detection based on circulating protein biomarkers and mutations in cfDNA from the blood. CancerEMC is generally designed for both binary cancer detection and multi-class cancer type localization. It can address the class imbalance problem in multi-analyte blood test data based on robust oversampling and adaptive synthesis techniques. Results Based on the clinical blood test data, we observe that the proposed CancerEMC has outperformed other algorithms and state-of-the-arts studies (including CancerSEEK published in Science, 2018) for cancer detection. The results reveal that our proposed method (i.e., CancerEMC) can achieve the best performance result for both binary cancer classification with 99.1748% accuracy (AUC = 0.999) and localized multiple cancer detection with 74.1214% accuracy (AUC = 0.938). For addressing the data imbalance issue with oversampling techniques, the accuracy can be increased to 91.4966% (AUC = 0.992), where the state-of-the-art method can only be estimated at 69.64% (AUC = 0.921). Similar results can also be observed on independent and isolated testing data. Availability https://github.com/saifurcubd/Cancer-Detection