This systematic review complies with the PRISMA statement. 22 Cochrane Library, Google Scholar, Elsevier and PubMed were systematically searched for RCTs from 1989 to 2018. Search terms were chemotherapy, randomised controlled trials, anemia, breast cancer, erythropoiesis stimulating agents, erythropoietin, epoetin, darbepoetin, methoxy polyethylene glycolepoetin beta, mortality, tumor progression, survival, quality of life, transfusion requirements and safety.
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