Effect of Erythropoiesis Stimulating Agents on Clinical Outcomes in Breast Cancer Patients: A Systematic Review of Randomised Controlled Trials

Abstract

This systematic review complies with the PRISMA statement. 22 Cochrane Library, Google Scholar, Elsevier and PubMed were systematically searched for RCTs from 1989 to 2018. Search terms were chemotherapy, randomised controlled trials, anemia, breast cancer, erythropoiesis stimulating agents, erythropoietin, epoetin, darbepoetin, methoxy polyethylene glycolepoetin beta, mortality, tumor progression, survival, quality of life, transfusion requirements and safety.

Results of darbepoetin alfa treatment of anaemia in chemotherapy-receiving breast cancer patients: a single-centre retrospective observational study

“…No statistically significant age-related differences were found in the effectiveness of ESA administration. Similar conclusions have been presented by other authors [13,23].…”

“…Chemotherapy-related anaemia constitutes one of the most common side effects in oncological patients [12,13]. According to various authors, the incidence of anaemia in breast cancer patients is estimated at 6-97% [13,14].…”

“…Chemotherapy-related anaemia constitutes one of the most common side effects in oncological patients [12,13]. According to various authors, the incidence of anaemia in breast cancer patients is estimated at 6-97% [13,14]. It has been most frequently reported in patients receiving docetaxel and carboplatin-based regimens [14,15].…”

“…Numerous studies dealing with anaemia treatment discuss the question of the safety of ESA and RBC transfusion application [13,24]. Both of these forms of treating anaemia involve the risk of thromboembolic complications.…”

Breast Cancer Research in Pakistan: A Bibliometric Analysis

“…Research on breast cancer is emerging at a rapid pace from around the world covering various aspects of the disease (Ahmadalizadeh Khanehsar et al, 2020; Arshi et al, 2019; Babteen et al, 2020; Demark-Wahnefried et al, 2020; Ihraiz et al, 2020; Jain Singhai & Ramteke, 2020; Najjary et al, 2020; Rahimi et al, 2020; Rezaee et al, 2020; Sun et al, 2020; Vidhya & Batri, 2020; Ye et al, 2020; Zeng et al, 2020). Pakistani researchers have been active in this regard as well (Aamir et al, 2020; Baig et al, 2020; Khan, Masroor et al, 2020; Khan, Rehman et al, 2020; Raza et al, 2020; Sabir et al, 2020; Shamsi et al, 2020; Wazir et al, 2020).…”