Approach-avoidance conflict arises when an animal encounters a stimulus that is associated simultaneously with positive and negative valences [1]. The effective resolution of approach-avoidance conflict is critical for survival and is believed to go awry in a number of mental disorders, such as anxiety and addiction. An accumulation of evidence from both rodents and humans suggests that the ventral hippocampus (anterior in humans) plays a key role in approach-avoidance conflict processing [2-8], with one influential model proposing that this structure modulates behavioral inhibition in the face of conflicting goals by increasing the influence of negative valences [9]. Very little is known, however, about the contributions of specific hippocampal subregions to this process-an important issue given the functional and anatomical heterogeneity of this structure. Using a non-spatial cue-based paradigm in rats, we found that transient pharmacological inactivation of ventral CA1 produced an avoidance of a conflict cue imbued with both learned positive and learned negative outcomes, whereas inactivation of the ventral CA3 resulted in the opposite pattern of behavior, with significant preference for the conflict cue. In contrast, dorsal CA1- and CA3-inactivated rats showed no change in conflict behavior, and furthermore, additional behavioral tasks confirmed that the observed pattern of approach-avoidance findings could not be explained by other factors, such as differential alterations in novelty detection or locomotor activity. Our data demonstrate that ventral CA1 and CA3 subserve distinct and opposing roles in approach-avoidance conflict processing and provide important insight into the functions and circuitry of the ventral hippocampus.

This article deals with q-starlike functions associated with conic domains, defined by Janowski functions. It generalizes the recent study of q-starlike functions while associating it with the conic domains. Certain renowned coefficient inequalities in connection with the previously known ones have been included in this work.

The hippocampus (HPC) has been widely implicated in the contextual control of appetitive and aversive conditioning. However, whole hippocampal lesions do not invariably impair all forms of contextual processing, as in the case of complex biconditional context discrimination, leading to contention over the exact nature of the contribution of the HPC in contextual processing. Moreover, the increasingly well-established functional dissociation between the dorsal (dHPC) and ventral (vHPC) subregions of the HPC has been largely overlooked in the existing literature on hippocampal-based contextual memory processing in appetitively motivated tasks. Thus, the present study sought to investigate the individual roles of the dHPC and the vHPC in contextual biconditional discrimination (CBD) performance and memory retrieval. To this end, we examined the effects of transient post-acquisition pharmacological inactivation (using a combination of GABA and GABA receptor agonists muscimol and baclofen) of functionally distinct subregions of the HPC (CA1/CA3 subfields of the dHPC and vHPC) on CBD memory retrieval. Additional behavioral assays including novelty preference, light-dark box and locomotor activity test were also performed to confirm that the respective sites of inactivation were functionally silent. We observed robust deficits in CBD performance and memory retrieval following inactivation of the vHPC, but not the dHPC. Our data provides novel insight into the differential roles of the ventral and dorsal HPC in reward contextual processing, under conditions in which the context is defined by proximal cues.

1The ventral hippocampus is thought to play a key role in the resolution of approach-avoidance 2 conflict, a scenario that arises when stimuli with opposing valences are present simultaneously. 3Little is known, however, about the contributions of specific hippocampal sub-regions in this 4 process, a critical issue given the functional and anatomical heterogeneity of this structure. Using 5 a non-spatial cue-based paradigm in rats, we found that transient pharmacological inactivation of 6 ventral CA1 produced an avoidance of a conflict cue imbued with both learned positive and 7 negative outcomes, whereas inactivation of the ventral CA3 resulted in the opposite pattern of 8 behavior, with significant preference for the conflict cue. In contrast, dorsal CA1-and CA3-9 inactivated rats showed no change in conflict behavior. Our findings provide important insight 10 into the functions and circuitry of the ventral hippocampus by demonstrating that the ventral CA1 11 and CA3 subserve distinct and opposing roles in approach-avoidance conflict processing. 12 peer-reviewed)

The infralimbic (IL) and prelimbic (PL) cortices of the medial prefrontal cortex (mPFC) have been shown to differentially control context-dependent behavior, with the PL implicated in the expression of contextually conditioned fear and drug-seeking, and the IL in the suppression of these behaviors. However, the roles of these subregions in contextually driven natural reward-seeking remain relatively underexplored. The present study further examined the functional dichotomy within the mPFC in the contextual control over cued reward-seeking, using a contextual biconditional discrimination (CBD) task. Rats were first trained to emit a nose poke response to the presentation of an auditory stimulus (e.g., X) for the delivery of sucrose reward, and to withhold a nose poke response to the presentation of another auditory stimulus (e.g., Y) in a context-specific manner (e.g. Context A: X+, Y−; Context B: X−, Y+). Following acquisition, rats received bilateral microinjections of GABA receptor agonists (muscimol and baclofen), or saline into the IL or PL, prior to a CBD training session and a probe test (under extinction conditions). Both IL and PL inactivation resulted in robust impairment in CBD performance, indicating that both subregions are involved in the processing of appetitively motivated contextual memories in reward-seeking.

In this paper, we introduce a new concept of q-bounded radius rotation and define the class R*m(q), m ≥ 2, q ∈ (0, 1). The class R*2(q) coincides with S*q which consists of q-starlike functions defined in the open unit disc. Distortion theorems, coefficient result and radius problem are studied. Relevant connections to various known results are pointed out.

Motivated by q-analogue theory and symmetric conic domain, we study here the q-version of the Ruscheweyh differential operator by applying it to the starlike functions which are related with the symmetric conic domain. The primary aim of this work is to first define and then study a new class of holomorphic functions using the q-Ruscheweyh differential operator. A new class k−STqτC,D of k-Janowski starlike functions associated with the symmetric conic domain, which are defined by the generalized Ruscheweyh derivative operator in the open unit disk, is introduced. The necessary and sufficient condition for a function to be in the class k−STqτC,D is established. In addition, the coefficient bound, partial sums and radii of starlikeness for the functions from the class of k-Janowski starlike functions related with symmetric conic domain are included.

Substitution box ( -box), being the only nonlinear component, contributes to the confusion creating capability of a cryptosystem. Keeping in view the predominant role of -box, many design algorithms to synthesize cryptographically stronger -boxes have gained pivotal attention. A quick review of these algorithms shows that all these ideas mainly concentrate on the choice of bijective Boolean functions, with nonobservance to the irreducible polynomial that generates the Galois field. In this paper, we propose that the selection of irreducible polynomial has a deep influence on the highly desirable features of an -box such as nonlinearity, strict avalanche, bit independence, linear approximation probability, and differential approximation probability. We underpin our claim by investigating a detailed model, which deploys the same algorithm but different polynomials and produces unusual changes in the results regarding the performance parameters of -box.