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To investigate and correlate total AgNOR area/Total nucleus area (TAA/TNA) values in buccal epithelial cells of healthy individuals in different age groups. In present study 50 healthy individuals are included with age ranging 10 to 60 years. These are divided into 5 groups. Group 1-10-20 year, Group2-20- 30year, Group3-30- 40year, Group 4-40-50-year, Group 5-50-60 year. Oral epithelial cells collected with the help of cyto brush from buccal mucosa. Smears were prepared on clean glass slides and fixed with 95% alcohol. Fixed slides Smears were stained with AgNOR stain. Statistically significant correlations were found between mean TAA/TNA values and age p < 0.001 for linear and p < 0.0001 for polynominal regression, and between AgNOR number and age, p < 0.001 for linear. There is a significant correlation between age and AgNOR amount (ribosome biosynthesis rate) in buccal epithelial cells of healthy individuals. AgNORs in buccal epithelial cells may be used for detection of age

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Stem cells are cells that have the ability to continuously divide and produce progeny that differentiate into various other types of cells or types of tissues. In the battle to fight against diseases, stem cells present potencies to repair tissues by cell therapy and tissue regeneration. The study of stem cells turns to be a major frontier in 21th century biology and medicine. Recently, dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs) have been isolated from dental pulp tissue of adult permanent teeth and deciduous teeth, respectively. The present article highlights the origin and class-ification of stem cells with their applications in the field of medicine and dentistry. Despite promising scientific results with genetically modified stem cells, some major problems remain to be overcome. Strategies that combine gene targeting with embryonic stem cellbased therapy are thus potential novel therapeutic options. Further research is essential to determine the full potential of both adult and embryonic stem cells in this exciting new field.

Background: Temporomandibular joint (TMJ) is a stress bearing structure. Its resilience and functions are supported by collagen architecture. Visualization of this collagen networking can be done under polarizing microscope. This network gets modified in a variety of conditions affecting the TMJ like-ankylosis, degenerative joint disorder, neoplastic conditions, trauma and ageing. The objective of this study is to analyze the histomorphological changes in TMJ conditions and correlate them with collagen architecture so as to project scoring criteria for distinguishing between osseous changes. Methods: Paraffin based H and E sections of TMJ conditions were obtained and observed under polarizing microscopy. Sample distribution was as follows: Degenerative joint disease (n=10), ankylosis (n=5) and osteochondroma (n=5). A scoring criterion was devised and cutoff value was determined. Results: Immature or formative tissue was found to have a score of less than and equal to five and mature tissue had a score of greater than and equal to six. Conclusion: Scoring criterion proposed in this study is a reliable technique and can be used for confirming the histological architectural changes within a diseased TMJ.

Non-Hodgkin's lymphomas belong to a group of neoplasm originating from the cells of the lymphoreticular system that show diversity in their manner of presentation, response to therapy and prognosis. Non-Hodgkin's lymphoma accounts for 80–90% of all lymphomas. Although primary intraoral lesions in non-Hodgkin's lymphoma are uncommon, it is important to be aware of them as intraoral manifestations are a presenting symptom in these patients. A 72-year-old Indian male presented with a complaint of asymptomatic swelling in the left side of the face since 1.5 months. A careful clinical evaluation supported by radiologic, histopathologic and immunohistochemical investigations will help in identifying the disease at an early stage, which will result in better prognosis.