Comprehensive evaluation of cortical structure abnormalities in drug-naïve, adult patients with obsessive-compulsive disorder: A surface-based morphometry study

Venkatasubramanian, Ganesan; Zutshi, Amit; Jindal, Sachin; Srikanth, S. G.; Kovoor, J.M.E.; Kumar, J. Keshav; Reddy, Y.C. Janardhan

doi:10.1016/j.jpsychires.2012.06.003

Cited by 47 publications

(54 citation statements)

References 74 publications

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“…Our results show a certain overlap with previous SBA studies in OCD samples: alterations in similar areas (i.e., parieto-occipital alterations, including the precuneus) partly overlap with the findings of Fan and colleagues, 20 and the same direction of alteration (i.e., decreases in volume and surface area) has been reported by Venkatasubramanian and colleagues. 19 However, whereas we found decreased grey matter surface area and volume in similar regions as Fan and colleagues, 20 their results showed mostly increased gyrification and thickness in those areas.…”

Section: Comparison With Surface-based Studiessupporting

confidence: 63%

“…Based on previous findings 19,20 we expected a significantly altered cortical morphology in these various grey matter measures in patients with OCD compared with controls. Additionally, we hypothesized that these structural alterations would be significantly associated with OCD psychopathology, which we investigated by correl ating the detected structural abnormalities with clinical scores (i.e., symptom severity).…”

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 72%

“…These alterations were partly associated with clinical characteristics (i.e., symptom severity, symptom type, disorder insight). Despite using the same method in an OCD sample with similar clinical characteristics (i.e., unmedicated patients), Fan and colleauges 20 found alterations that partly diverged from the findings of Venkatasubramanian and colleagues, 19 both regarding direction and location. Thus, the results by Fan and colleagues 20 revealed a significant increase in thickness in parietal areas and gyrification increases in a network containing the insula and frontal and occipital areas in patients with OCD that were positively associated with symptom severity.…”

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 88%

“…[16][17][18] To the best of our knowledge, only 2 studies have used the SBA approach in OCD samples to study gyrification, volume, surface area and thickness at the same time. 19,20 Venkatasubramanian and colleagues 19 applied SBA by using the automatic FreeSurfer software and provided first evidence of altered volume, surface area and thickness in a number of different regions comprising the ACC, OFC and occipital cortex in medication-naive patients with OCD. These alterations were partly associated with clinical characteristics (i.e., symptom severity, symptom type, disorder insight).…”

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 99%

“…The divergence in the direction of alteration may be partly driven by methodological differences in terms of clinical sample characteristics (i.e., previous studies investigated smaller samples and mainly unmedicated and comorbidityfree 20 or medication-naive patients 19 ). It is compelling that although other SBA studies 21,23,25,26,30,31 found grey matter thickness to be affected in patients with OCD, our results did not show such alterations in this measure, but we did find partly similar alterations in other measures.…”

Section: Comparison With Surface-based Studiesmentioning

confidence: 99%

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Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Rus

Reeß

Wagner

et al. 2017

JPN

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IntroductionStudying the brain anatomic structure offers a promising approach to improve our understanding of neural functional alter ations often encountered in individuals with psychiatric disorders. In those with obsessive-compulsive disorder (OCD), a psychiatric disorder with a 2%-3% lifetime prevalence 1 that causes strong impairment of daily life, findings up to now show disruptions on a functional and a structural neural level, mainly in a network including cortico-striatothalamo-cortical (CSTC) areas. Overall, these findings are rather inconsistent and limited by confounding factors, such as differences in clinical characteristics of the study sample or varying methodological approaches.Meta-analytic reviews showed that cortical areas, mainly the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC) and parietofrontal regions, seem to be predominantly affected by grey matter volume deficits in patients with OCD, whereas the lenticular nuclei and thalamus were found to be characterized by increases in grey matter volume.2-4 A recent review article 5 confirmed these results and concluded that structural alterations in patients with OCD are widespread and occur most probably at a network level, with cortical tissue reductions and a tendency toward increases in grey matter volume of subcortical limbic areas. These subcortical tissue increases were also corroborated by a recent meta/mega-analysis of the ENIGMA OCD imaging consortium. 6 Additionally, this meta/mega-analysis showed that the neuroplasticity of specific areas depends on the age of the studied sample (i.e., smaller hippocampal but larger pallidum volumes were prominent in adults with OCD, whereas only larger thalamic volumes were specific for pediatric patients). Besides grey matter volume alterations in patients with OCD, significantly decreased grey matter thickness in partly overlapping areas (i.e., limbic, parietal and temporal areas) was also found in another recent mega-analysis. 7 It is Background: Mounting evidence indicates the presence of structural brain alterations in individuals with obsessive-compulsive disorder (OCD). Findings are, however, rather heterogeneous, which may be partly because of differences in methodological approaches or clinical sample characteristics. The aim of the present study was to analyze the whole brain cortical volume, surface area and thickness in a large sample of patients with OCD compared with age-and sex-matched healthy controls. Methods: We conducted whole brain surfacebased analyses of grey matter measures using the automated FreeSurfer software in patients with OCD and matched controls. Group analyses were performed and corrected for multiple testing using Monte Carlo simulations (p < 0.05). Altered brain regions and their average morphological values were associated to symptom severity and type (Yale-Brown Obsessive Compulsive Scale scores). Results:We included 75 patients and 75 controls in our analyses. Patients with OCD showed decreases in both volume and surface area compared with healthy ...

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Section: Comparison With Surface-based Studiessupporting

confidence: 63%

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 72%

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 88%

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 99%

Section: Comparison With Surface-based Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Rus

Reeß

Wagner

et al. 2017

JPN

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show abstract

Cortical thickness and white matter integrity abnormalities in obsessive-compulsive disorder: A combined multimodal surface-based morphometry and tract-based spatial statistics study

Zhou

Ping

et al. 2018

Depress Anxiety

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Network‐based decoupling of local gyrification in obsessive‐compulsive disorder

Reeß

Rus

Gürsel

et al. 2018

Human Brain Mapping

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Gyrification is associated with cortical maturation and closely linked to neurodevelopmental processes. Obsessive-compulsive disorder has previously been associated with neurodevelopmental risk factors. Using graph theoretical modeling we examined structural covariance patterns to assess potential disruptions in processes associated with neurodevelopment in OCD. In total 97 patients and 92 healthy controls underwent magnetic resonance imaging. Structural covariance networks based on local gyrification indices were constructed using an atlas-based parcellation scheme. Network properties were assessed using the network-based statistic as well as global and local graph theoretical measures. Correlations between gyrification and symptom severity as well as age of disease onset were examined. Network-based statistic analysis revealed one cluster with significantly decreased structural covariance in patients comprising mainly ventral brain regions (p = .041). Normalized characteristic path length was found to be impaired in patients (p = .051). On a nodal level, left middle frontal sulcus displayed a significantly decreased local clustering coefficient (p < .001). Finally, gyrification in several inferior frontal nodes significantly correlated with age of onset but not symptom severity. The decrease in a gyrification-based covariance network in OCD appears to be mostly confined to ventral areas in which gyrification starts the latest during development. This pattern may indicate that alterations taking place during development are potentially time locked to specific periods. Correlations between gyrification in inferio-frontal nodes and age of onset potentially indicate a structural trait rather than state marker for OCD. Finally, a trend in impaired global integration capabilities may point towards potentially widespread global alterations during neurodevelopment in patients.

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Comprehensive evaluation of cortical structure abnormalities in drug-naïve, adult patients with obsessive-compulsive disorder: A surface-based morphometry study

Cited by 47 publications

References 74 publications

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Cortical thickness and white matter integrity abnormalities in obsessive-compulsive disorder: A combined multimodal surface-based morphometry and tract-based spatial statistics study

Network‐based decoupling of local gyrification in obsessive‐compulsive disorder

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