Background: Childhood obesity is associated with a higher chance of premature death and disability in adulthood, according to the World Health Organization. More than two-thirds of the adolescents aged 11-17 years are physically inactive in India as per WHO standards. Hence, school based Healthy life style curriculum development is the need of the hour for school children. The objectives of the study were to promote healthy lifestyle, by implementing school based intervention program (physical activity and nutrition education) for healthy body mass index among school children; to study the correlation between the body mass index and academic performance (secondary objective).Methods: A quasi-experimental study was conducted in the randomly selected schools of Bagalkot. A total of 598 students in intervention group and 575 students in control group participated in the study. Baseline information about demographic characteristics was obtained using pre-designed proforma. For intervention group, multicomponent programme was implemented based on child and adolescent trial for cardiovascular health model and the comprehensive school health programme model by the USA, centre for disease control. After 2 years, post-interventional data was collected.Results: In pre-test intervention group majority of participants (37.4%) were having normal BMI, while 26.8% participants were obese. In post-test intervention group majority of participants (45.7%) were having normal BMI, while 23.1% participants were obese. In pre-test control group majority of participants (34.7%) were having normal BMI, while 27.1% participants were obese. In post-test control group majority of participants (38.7%) were having normal BMI, while 26.4% participants were obese. Majority of the students attained normal BMI after the intervention. BMI of the participants is negatively correlated to academic performance (r=-0.025).Conclusions: The life style changes such as physical activity, yoga and meditation are the need of the hour among the schoolchildren, helps in maintenance of healthy BMI.
Atopic dermatitis (AD) is the most common inflammatory disease of the skin characterized by defects in keratinocyte differentiation and skin barrier dysfunction. Despite its prevalence, an in vitro,commercial model of AD is not currently available to facilitate basic research and therapeutic development. Using the reconstructed full thickness human epidermal model (EpiDermFT), an inflammatory cocktail comprised of Th2 cytokines was used to induce changes to mimic an atopic dermatitis phenotype. Following treatment with IL-4, IL-13 and IL-31, significant changes in several markers of differentiation and skin barrier integrity were observed, closely resembling AD skin. Histological analysis revealed treatment with IL-4, IL-13, and IL-31 reduced the presence of the stratum granulosum and induced spongiosis in the epidermis. Upregulation of pro-inflammatory mediators, such as IL-8, and down regulation of differentiation markers (keratin 1, keratin 10, involucrin, filaggrin) were observed at both the gene and protein level. These findings demonstrate that treatment of the EpiDermFT tissue model with Th2 cytokines induces a phenotype that is consistent with the hallmarks of AD, including altered differentiation and barrier function. We anticipate that the model described here will be useful for screening and evaluating active ingredients and other molecules used in the treatment of atopic dermatitis. LB1588 Ultraviolet light-induced gasdermin c expression is mediated via trpv1/ calcium/calcineurin/nfatc1 pathway
Background: The destitute centre was established in 1992, 14th August; situated in Karnataka with a built up area is 29 acres and has 33 males and 17 female inmates. The patients here can be classified as having psychiatric illness, destitute with general co morbid conditions and wandering tramps with normal mentation. The study was done to know the morbidity profile among the inmates of destitute centre and to assess the change in the quality of life before the morbidity assessment and after medication and treatment.Methods: It was a pre-post evaluation study done from August 2012 to December 2012. All of the 50 resident inmates of the destitute centre were evaluated before and after clinical examination and treatment with General Well Being Scale (GWBS).Results: Among the total inmates, 06 (12%) were in age group 20-29 years, 11 (22%) belonged to 30-39 years, 10 (20%) belonged to 40-49 years, 09 (18%) each belonged to 50-59 and 60-69 years age group respectively, 04 (8%) belonged to 70-79 years and 01 (2%) of the elderly belonged to age ≥80 years of age. 38 (76.0%) were males and 12 (24%) were females. Majority of the inmates i.e. 42 (84.0%) belonged to broken families, about 4(8.0%) elderly belonged to problem families. 18 (36.0%) consumed tobacco, about 07 (14.0%) were either smoking or consuming alcohol, about 02 (4.0%) had both alcohol and smoking habits.Conclusions: 74% of them had psychiatric comorbidities and these were likely to cause significant functional impairment. Appropriate treatment helped 5 (10%) individuals to be shifted to rehabilitation center.
INTRODUCTIONAgeing is a universal phenomenon and the population of elderly is on the rise, with current estimates of 8.8% in urban areas in developing areas. 1 With the increase in the number of nuclear families especially in the urban areas the senior citizens have been experiencing lot of age related morbidities predominant being Alzheimer's dementia and the burden associated with the caregivers of such patients is enormous. ObjectiveTo assess the burden of the caregivers of cognitively impaired elderly, residing in an urban area. ABSTRACT Background:The population of elderly is on the rise with estimates of 8.8% in urban area. Increase in the number of nuclear families, specially in the urban areas the elderly have been experiencing multiple morbidities, predominantly dementia and the burden associated with the caregivers of such elderly is enormous. Thus the study was undertaken to assess the burden of the caregivers of cognitively impaired elderly, residing in an urban area. Methods: It was a Cross sectional study in an Urban Health Centre, field practice area, of JN Medical College, KLE University, Belagavi of North Karnataka from 1 st January to 31 st December 2012. Among the 783 elderly, >60 years, assessed for cognitive impairment using Mini Mental State Examination/Hindi Mini Mental State Examination for literate /illiterate respectively, 55 elderly were cognitively impaired (MMSE/HMSE score<25). Caregivers of these 55 elderly who were permanent residents of the field practice area (Residing for one year with demented elderly) were interviewed using Zarit Caregiver Burden Scale (ZBI) to assess for emotional, financial, social burnout. Results: 22 (40.00%) Caregivers were males and 33 (60.00%) were females. 07(12.73%) had studied up to primary school, 15 (27.27%) up to high school, 24 (43.64%) up to Pre-university degree 01(1.81%) had completed diploma and 8(14.55%) caregivers were graduates. 16 (29.09%) of them had a ZBI scale score between 21 to 40 (mild to moderate burden), 38 (69.09%) scored between 41 to 60 (Moderate to severe burden) and 1 (1.82%) scored between 61-88 and experienced severe burden. Conclusions: Majority 60.0% of the caregivers were women in the productive age group of 21-40 years. Had to take the dual responsibility of care-taking and working plus raising up their children. The caregivers of cognitively impaired elderly, majority of them experienced a lot of physical, emotional, psychological stress and strain. Maximum of the caregivers were over taxed with responsibilities and felt that all responsibility fell on one caregiver (dependence burden).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.