Bu çalışmanın amacı, oral çinko sülfatın psoriazis tedavisinde tek başına ve metotreksat ile kombine edildiğinde etkinliğini araştırmaktır. Gereç ve yöntem:Toplam 60 psöriazis vulgaris'li hasta Ekim 2006 -Ekim 2007 tarihleri arasında çalışmaya alındı. Hastalar sistemik tedavilerine göre aşağıdaki gibi üç gruba ayrıldı: Grup 1 (20 hasta) oral çinko sülfat ile tedavi edilenler; Grup 2 (20 hasta) oral çinko sülfat+ oral metotreksat ile tedavi edilenler ve Grup 3 (20 hasta) tek başına oral metotreksat ile tedavi edilenler.Bulgular: Çalışmaya 34 (%56.7) erkek ve 26 kadın (%43.3) hasta (Erkek/Kadın oranı: 1.3/1) alındı. Oral çinko sülfat alan grupta hastaların yaklaşık %60'ında iyi sonuç alındı ve bu grupta tedavi kesilmesinden 4 hafta sonra hastaların %58'inde relaps gelişti. Oral çinko sülfat+Oral metotreksat kombinasyonu hastaların %85'inde iyi sonuç verdi ve tedavi kesilmesinden dört hafta sonra bu grupta %59 oranında relaps gözlendi. Tek başına metotreksat %70 hastada iyi sonuç verdi ve bu grupta tedavi kesilmesini takiben %64 hastada relaps gelişti. Oral çinko sülfat grubunda %30 hastada hafif yan etkiler gözlendi Sonuç: Çinko sülfat psöriazis tedavisinde etkilidir, ancak çinko sülfat+Metotreksat kombinasyonu tek başına çinko sülfat veya metotreksat'tan daha etkili gözükmektedir.

Nanoparticle science is currently an area of intense scientific research due to a wide range of possible applications in the biomedical and electronic fields. Nanoparticle works as an important bridge between bulk materials and atomic or molecular structures. The aim of this study is to evaluate the preparation of clove buds by extraction and encapsulation using nanoprecipitation technique with selenium nanoparticles. The nanoparticles are prepared by nanoprecipitation technique and characterized by particles sizers, UV spectrophotometers, and scanning electron microscopy (SEM) images which were utilized for regular distribution and spherical shape of nanoparticles with the size range of 206.5 nm; active compounds were detected by Gas chromatography-mass spectrometry (GC-MS). The antioxidant activity of clove nanoparticles was evaluated against hepatotoxic thioacetamide in male rats. 30 albino male rats were divided into 6 groups, with 5 rats in each group. All groups of animals were treated with single dose of Thioacetamide100 mg/kg except the control. Groups T2 and T3 received Thioacetamide (100)/kg) I.p., treated orally with 100 mg/kg of clove extract and clove nanoparticles of dose by day respectively, while the last group was treated with selenium nanoparticles at dose 0.5 mg/kg daily. The selenium loaded clove nanoparticles showed spherical shape with seller size of 206.5 nm. GCMS of Syzygium aromaticum (clove) contained more than 13 active compounds. Consequently, the cytogenic study of clove nanoparticles showed a clear reducing of micronuclei percentages, chromosomal aberration and their types. In addition, the serum evaluated in this study showed significant reduction of TNFa ng/dl and IL6 in rats treated with clove extract and clove-nanoparticles in comparison with thioacetamide alone. Interestingly, the antioxidant activity of GPX was significantly elevated in rats having received clove-nanoparticles. Additionally, the histopathological defect such as inflammation and necrosis in liver and kidney was cured by using clove nanoparticles. The clove loaded selenium nanoparticles illustrated strong antioxidant and scavenging activities led by alleviate cytogenic and tissue damage induced by thioacetamide.

The diabetic mellitus (DM) disease is a danger risk and a cause for rising public health anxietyat both develop and non-developing countries. T2DM is described by insulin resistances and/or abnormal insulin secretions from pancreas. Dehydroepiandrosterone sulfate: is a significant mammalian steroid hormone, the synthesis of this hormone from pregnenolone in the body. DHEA is a source of production of other hormones that the body need like estrogens and testosterone. Objectives: To study Serum DHEA-S hormone estimationas predictor of T2DM in relative with other limitations in diabetic patient. Material and Method: the study designed as case control experimental study was conducted on diabeticpatient at Al-Seder Hospital at AL-Najaf City-Iraq from February to April 2020. Results: the results of this study show there is significantly differences in (p< 0.05) between T2DM patients and control group, there is significant decrease in DHEA-S hormone levels at patient, while in regarding to thyroid hormones the T3 and T4 were significantly decrease on other hand TSH was increased. The lipid and sugar profiles were significantly increased at (P< 0.05). Conclusion: our study conducted There is a main relationship between DHEA-S hormone level and T2DM. This supports that DHEA-S level is reversely related with the diabetes progression.

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