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Tracheal mucous velocity (TMV) was measured in experimental canine asthma. All 10 sensitive dogs exposed to an aerosol of Ascaris suum extract showed a decrease in TMV to about one-third of base-line values within 45 min whereas only half of them (reactors) responded with bronchospasm as measured by a significant reduction in specific respiratory system conductance (SGrs). Mean TMV remained decreased at the end of the 2-h observation period when mean SGrs had returned to base-line values in the reactors. Neither TMV nor SGrs changed in nonsensitive animals who inhaled ragweed antigen. Aerosols of acetylcholine and histamine increased TMV thereby excluding these mediators as responsible for the impairment of mucous transport in asthma. Nebulization of A. suum antigen together with a selective antagonist of slow reacting substance of anaphylaxis (srs-a) produced a marked increase of TMV in all dogs regardless of whether or not bronchospasm was elicited. This suggests that the observed decrease in TMV may be related to the release of SRS-A during the immunologic reaction.

The influence of lung inflation on the cross-sectional area of the trachea and main bronchi was investigated in 2 normal subjects, 2 patients with emphysema, and 1 patient with pulmonary fibrosis. Fiberoptic cinebronchoscopy was used to measure the cross-sectional area of the airways using calibrated small Teflon discs placed on the airway wall as reference. As an estimate of airway compliance at intermediate lung volumes, radial distensibility was defined as the change in cross-sectional area per change in airway pressure minus esophageal pressure divided by the cross-sectional area at functional residual capacity. Both in normal subjects and in patients with emphysema, the radial distensibility was larger in the trachea than in the main bronchi without differences between the right and left main bronchus. The area-pressure curves revealed alinearity and hysteresis in both groups with an increased distensibility in pulmonary emphysema. In a patient with pulmonary fibrosis, the distensibility was decreased by a factor of ten and the area-pressure curve was linear. These observations suggest altered static mechanics of extraparenchymal, intrathoracic airways in patients with pulmonary emphysema and fibrosis.