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The electrical creation and detection of spin accumulation in p-type Ge were successfully demonstrated at room temperature by spin-polarized tunneling in epitaxial Fe/MgO contacts on Ge with a hole concentration of 8×1018 cm-3. In Hanle measurements, the spin accumulation produces a spin signal of about 40 µV per mA of tunnel current. The extracted spin lifetime of holes is 13 ps, which is much longer than the momentum relaxation time. The corresponding spin-diffusion length is 80 nm, suggesting that communication of spin information in p-type Ge is possible over the typical channel length of a field-effect transistor.

Anomalous scaling of spin accumulation in ferromagnetic tunnel devices with silicon and germanium Sharma, S.; Spiesser, A.; Dash, S.P.; Iba, S.; Watanabe, S.; Wees, B.J. van; Saito, H.; Yuasa, S.; Jansen, R. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. The magnitude of spin accumulation created in semiconductors by electrical injection of spin-polarized electrons from a ferromagnetic tunnel contact is investigated, focusing on how the spin signal detected in a Hanle measurement varies with the thickness of the tunnel oxide. An extensive set of spin-transport data for Si and Ge magnetic tunnel devices reveals a scaling with the tunnel resistance that violates the core feature of available theories, namely, the linear proportionality of the spin voltage to the injected spin current density. Instead, an anomalous scaling of the spin signal with the tunnel resistance is observed, following a power law with an exponent between 0.75 and 1 over 6 decades. The scaling extends to tunnel resistance values larger than 10 9 μm 2 , far beyond the regime where the classical impedance mismatch or back flow into the ferromagnet play a role. This scaling is incompatible with existing theory for direct tunnel injection of spins into the semiconductor. It also demonstrates conclusively that the large spin signal does not originate from two-step tunneling via localized states near the oxide/semiconductor interface. Control experiments show that spin accumulation in localized states within the tunnel barrier or artifacts are also not responsible. Altogether, the scaling results suggest that, contrary to all existing descriptions, the spin signal is proportional to the applied bias voltage, rather than the (spin) current.

Spin accumulation induced in p-type germanium from Fe/MgO tunnel contacts is studied as a function of hole concentration p (10^16 - 10^19 cm-3). For all p, the contacts are free of rectification and Schottky barrier, guaranteeing spin injection into the Ge and preventing spin accumulation enhancement by two-step tunneling via interface states. The observed spin accumulation is smallest for nondegenerate doping (p ~ 10^16 cm-3) and increases for heavily doped Ge. This trend is opposite to what is expected from spin injection and diffusion theory. For heavily doped Ge, the observed spin accumulation is orders of magnitude larger than predicted.Comment: To appear in Appl. Phys. Expres

Recent reports show that efonidipine, a dihydropyridine Ca2+ antagonist, has blocking action on T-type Ca2+ channels, which may produce favorable actions on cardiovascular systems. However, the effects of other dihydropyridine Ca2+ antagonists on T-type Ca2+ channels have not been investigated yet. Therefore, in this study, we examined the effects of dihydropyridine compounds clinically used for treatment of hypertension on a T-type Ca2+ channel subtype, alpha1G, expressed in Xenopus oocytes. These effects were compared with those on T-type Ca2+ channel. Rabbit L-type (alpha1Calpha2/deltabeta1a) or rat T-type (alpha1G) Ca2+ channel was expressed in Xenopus oocytes by injection of cRNA for each subunit. The Ba currents through expressed channels were measured by conventional 2-microelectrode voltage-clamp methods. Twelve DHPs (amlodipine, barnidipine, benidipine, cilnidipine, efonidipine, felodipine, manidipine, nicardipine, nifedipine, nilvadipine, nimodipine, nitrendipine) and mibefradil were tested. Cilnidipine, felodipine, nifedipine, nilvadipine, minodipine, and nitrendipine had little effect on the T-type channel. The blocks by drugs at 10 microM were less than 10% at a holding potential of -100 mV. The remaining 6 drugs had blocking action on the T-type channel comparable to that on the L-type channel. The blocking actions were also comparable to that by mibefradil. These results show that many dihydropyridine Ca2+ antagonists have blocking action on the alpha1G channel subtype. The action of dihydropyridine Ca2+ antagonists in clinical treatment should be evaluated on the basis of subtype selectivity.

Synovial fibroblasts contribute to the inflammatory temporomandibular joint under pathogenic stimuli. Synovial fibroblasts and T cells participate in the perpetuation of joint inflammation in a mutual activation feedback, via secretion of cytokines and chemokines that stimulate each other. IL-17 is an inflammatory cytokine produced primarily by Th17 cells which plays critical role in the pathogenesis of numerous autoimmune and inflammatory diseases. Here, we investigated the roles of IL-17A in temporomandibular joint disorders (TMD) using genome-wide analysis of synovial fibroblasts isolated from patients with TMD. IL-17 receptors were expressed in synovial fibroblasts as assessed using real-time PCR. Microarray analysis indicated that IL-17A treatment of synovial fibroblasts upregulated the expression of IL-6 and chemokines. Real-time PCR analysis showed that the gene expression of IL-6, CXCL1, IL-8, and CCL20 was significantly higher in IL-17A-treated synovial fibroblasts compared to nontreated controls. IL-6 protein production was increased by IL-17A in a time- and a dose-dependent manner. Additionally, IL-17A simulated IL-6 protein production in synovial fibroblasts samples isolated from three patients. Furthermore, signal inhibitor experiments indicated that IL-17-mediated induction of IL-6 was transduced via activation of NFκB and phosphatidylinositol 3-kinase/Akt. These results suggest that IL-17A is associated with the inflammatory progression of TMD.

Interference of spin-up and spin-down eigenstates depicts spin rotation of electrons, which is a fundamental concept of quantum mechanics and accepts technological challenges for the electrical spin manipulation. Here, we visualize this coherent spin physics through laser spin-and angle-resolved photoemission spectroscopy on a spin-orbital entangled surface-state of a topological insulator. It is unambiguously revealed that the linearly polarized laser can simultaneously excite spin-up and spin-down states and these quantum spin-basis are coherently superposed in photoelectron states. The superposition and the resulting spin rotation is arbitrary manipulated by the direction of the laser field. Moreover, the full observation of the spin rotation displays the phase of the quantum states. This presents a new facet of laser-photoemission technique for investigation of quantum spin physics opening new possibilities in the field of quantum spintronic applications.PACS numbers: 73.20. At, Coherent manipulation of electron spin offers many potential applications in spintronic devices [1] and spinbased quantum information science [2,3]. The key is to take control over the superposition of spin-up and spindown states resulting in interference. Spin-orbit coupling (SOC) mediates electric field and electron spin; thus electric/optical control of spins may become possible. Up to now, the coherent spin manipulation through electric fields is demonstrated in a few systems, such as quantum qubits [3,4] and semiconductor-heterostructure interfaces [5]. Optical control of spins utilizing the superimposed states in diamond is also demonstrated [6]. In this Letter we introduce a great methodology which is capable of directly accessing this scheme in photoelectron spin, based on a combination of polarization-variable laser with spin-and angle-resolved photoemission spectroscopy (laser-SARPES).We use the technique for a well-understood model system, a spin-polarized surface state of a topological insulator (TI), Bi 2 Se 3 . The TI has been discovered as a new class of matter, which is characterized by a metallic topological surface-state (TSS) intersecting the bulk bandgap [7,8]. The TSS forms spin-polarized Dirac-cone-like energy dispersion [9][10][11][12][13][14]. In particular, as a consequence of the strong SOC, different spins and orbitals are mixed in the TSS wavefunction, which generates a spin-orbital entangled texture [15][16][17]. Since the electric field of light couples to the orbitals, polarized light can, in princi- * These two authors contributed equally. † kuroken224@issp.u-tokyo.ac.jp ‡ komori@issp.u-tokyo.ac.jp ple, selectively excite the fully spin-polarized electrons with either spin-up or spin-down from the spin-orbital entanglement. The spin-selective excitation in the TSS by polarized light was theoretically studied [18,19] and demonstrated in previous SARPES experiments [20][21][22][23]. The entangled spin-orbital texture of the TSS is therefore suitable for the coherent spin control as a novel source of spin...

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