Reliable diagnosis of depressive disorder is essential for both optimal treatment and prevention of fatal outcomes. This study aimed to elucidate the effectiveness of two non-linear measures, Higuchi's Fractal Dimension (HFD) and Sample Entropy (SampEn), in detecting depressive disorders when applied on EEG. HFD and SampEn of EEG signals were used as features for seven machine learning algorithms including Multilayer Perceptron, Logistic Regression, Support Vector Machines with the linear and polynomial kernel, Decision Tree, Random Forest, and Naı ¨ve Bayes classifier, discriminating EEG between healthy control subjects and patients diagnosed with depression. This study confirmed earlier observations that both non-linear measures can discriminate EEG signals of patients from healthy control subjects. The results suggest that good classification is possible even with a small number of principal components. Average accuracy among classifiers ranged from 90.24 to 97.56%. Among the two measures, SampEn had better performance. Using HFD and SampEn and a variety of machine learning techniques we can accurately discriminate patients diagnosed with depression vs controls which can serve as a highly sensitive, clinically relevant marker for the diagnosis of depressive disorders.

ObjectivesBiomarkers of major depressive disorder (MDD), its phases and forms have long been sought. Objectives were to examine whether the complexity of EEG activity, measured by Higuchi's fractal dimension (HFD) and sample entropy (SampEn), differs between healthy subjects, patients in remission, and in episode phase of the recurrent depression and whether the changes are differentially distributed between hemispheres and cortical regions.MethodsResting state EEG with eyes closed was recorded from 22 patients suffering from recurrent depression (11 in remission, 11 in the episode), and 20 age and sex‐matched healthy control subjects. Artifact‐free EEG epochs were analyzed by in‐house developed programs running HFD and SampEn algorithms.ResultsDepressed patients had higher HFD and SampEn complexity compared to healthy subjects. The complexity was higher in patients who were in remission than in those in the acute episode. Altered complexity was present in the frontal and centro‐parietal regions when compared to control group. The complexity in frontal and parietal regions differed between the two phases of depressive disorder.ConclusionsComplexity measures of EEG distinguish between the healthy controls, patients in remission and episode. Further studies are needed to establish whether these measures carry a potential to aid clinically relevant decisions about depression.

No abstract

No abstract

Purpose The control of a quadrotor unmanned aerial vehicle (UAV) is a challenging problem because of its highly nonlinear dynamics, under-actuated nature and strong cross-couplings. To solve this problem, this paper aims to propose a robust control strategy, based on a concept of active disturbance rejection control (ADRC). Design/methodology/approach The altitude/attitude dynamics of a quadrotor is reformulated into the ADRC framework. Three distinct variations of the error-based ADRC algorithms, with different structures of generalized extended state observers (GESO), are derived for the altitude/attitude trajectory-following task. The convergence of the observation part is proved based on the singular perturbation theory. Through a frequency analysis and a quantitative comparison in a simulated environment, each design is shown to have certain advantages and disadvantages in terms of tracking accuracy and robustness. The digital prototypes of the proposed controllers for quadrotor altitude and attitude control channels are designed and validated through real-time hardware-in-the-loop (HIL) co-simulation, with field-programmable gate array (FPGA) hardware. Findings The effects of unavailable reference time-derivatives can be estimated by the ESO and rejected through the outer control loop. The higher order ESOs demonstrate better performances, but with reductions of stability margins. Time-domain simulation analysis reveals the benefits of the proposed control structure related to classical control approach. Real-time FPGA-based HIL co-simulations validated the performances of the considered digital controllers in typical quadrotor flight scenarios. Practical implications The conducted study forms a set of practical guidelines for end-users for selecting specific ADRC design for quadrotor control depending on the given control objective and work conditions. Furthermore, the paper presents detailed procedure for the design, simulation and validation of the embedded FPGA-based quadrotor control unit. Originality/value In light of the currently available literature on error-based ADRC, a comprehensive approach is applied here, which includes the design of error-based ADRC with different GESOs, its frequency-domain and time-domain analyses using different simulation of UAV flight scenarios, as well as its FPGA-based implementation and testing on the real hardware.