Mongrel dogs receiving wolf kidney grafts were treated with Cyclosporin A. The kinetics of the inflammatory response and the display of major histocompatibility (MHC) antigens on graft tubular cells were analyzed by transplant aspiration cytology. Tubular cells aspirated from grafts that underwent repeated rejection episodes showed a higher degree of MHC antigen expression than cells obtained from a well-functioning graft.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.