Synthesis of Non-Glucoside Analogues of 6-Azacytidine and 6-Azauridine -(such as (II) based on the oxidative cleavage of the carbohydrate moiety of corresponding nucleosides). -(OGNYANIK, S. S.; SHALAMAI, A. S.; ALEKSEEVA, I. V.; LYSENKO, N. A.; Ukr. Khim. Zh. (Russ. Ed.) 61 (1995) 5-6, 52-55; Inst. mol., biol. genet. Nats. Akad. nauk Ukr., Kiev, Ukraine; UK)
Synthesis and Biological Activity of N1-Substituted 6-Azacytosines.-The synthesis of a range of N1-furanyl substituted azapyrimidine bases is based on the alkylation of corresponding silylated bases with acetoxyfuran derivatives. The products display inhibitory effects on leukosis in vivo; however, their activity is somewhat inferior than those of the reference agent 6-azacytidine. -(ALEKSEEVA, I. V.; PAL'CHIKOVSKAYA, L. I.; SHA-LAMAI, A. S.; OGNYANIK, S. S.; MORGART, N. V.; PETRUSHA, N. A.; Khim.-Farm. Zh. 28 (1994) 4, 16-18; Inst. mol. biol. gen. Akad. nauk Ukrainy, Kiev, Ukraine; RU)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.