ChemInform Abstract: Synthesis and Biological Activity of N1‐Substituted 6‐Azacytosines.

Abstract

Synthesis and Biological Activity of N1-Substituted 6-Azacytosines.-The synthesis of a range of N1-furanyl substituted azapyrimidine bases is based on the alkylation of corresponding silylated bases with acetoxyfuran derivatives. The products display inhibitory effects on leukosis in vivo; however, their activity is somewhat inferior than those of the reference agent 6-azacytidine. -(ALEKSEEVA, I. V.; PAL'CHIKOVSKAYA, L. I.; SHA-LAMAI, A. S.; OGNYANIK, S. S.; MORGART, N. V.; PETRUSHA, N. A.; Khim.-Farm. Zh. 28 (1994) 4, 16-18; Inst. mol. biol. gen. Akad. nauk Ukrainy, Kiev, Ukraine; RU)