X., 39 years old, was referred to the clinic of children's infectious diseases of Novosibirsk Medical Institute on 14.02.84 with the diagnosis: diphtheria polyneuritis with bulbar syndrome. Her husband and children were healthy. She denied any contacts with infectious diseases. Never had any previous illnesses. Has no recollection of vaccinations.
In recent years, ideas about the pathogenesis of various forms of meningococcal infection have expanded and changed considerably. Due to the significant increase in the proportion of meningococcal infections with toxic-infectious shock and the accompanying thrombohemorrhagic syndrome, it is important for practical medicine to thoroughly elucidate the pathogenetic mechanisms of these complications.
The indices of humoral and cellular immunity were studied in 10 patients with typical and 7 atypical (carriage) forms of diphtheria infection. The highest level of antibodies (4.25 1.2 AU / ml) was in carriers of diphtheria bacteria, and the lowest (0.07 AU / ml) was in patients with toxic diphtheria. Disturbances in the structure of cellular immunogomeostasis - a decrease in the total number of T-lymphocytes, an increase in Ta-ROK, an increase in the functional activity of phagocytic neutrophils and peripheral blood monocytes - were found in all and were most pronounced in patients with toxic diphtheria. In children, according to epidemiological indications, vaccinated with ADS, while the number of T-lymphocytes was preserved, all other studied parameters turned out to be increased.
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