Features of immunity in patients with diphtheria

Abstract

The indices of humoral and cellular immunity were studied in 10 patients with typical and 7 atypical (carriage) forms of diphtheria infection. The highest level of antibodies (4.25 1.2 AU / ml) was in carriers of diphtheria bacteria, and the lowest (0.07 AU / ml) was in patients with toxic diphtheria. Disturbances in the structure of cellular immunogomeostasis - a decrease in the total number of T-lymphocytes, an increase in Ta-ROK, an increase in the functional activity of phagocytic neutrophils and peripheral blood monocytes - were found in all and were most pronounced in patients with toxic diphtheria. In children, according to epidemiological indications, vaccinated with ADS, while the number of T-lymphocytes was preserved, all other studied parameters turned out to be increased.