These data are the first to identify an association between the ACE D-allele and DE in CCW. They provide evidence of a significant role for the RAS in the development of DE and suggest that clinical trials of ACE inhibition would be profitable in this group.
The aim of this investigation was to reveal a possible correlation between chromosomal aberrations and the health status of Chernobyl clean-up workers who suffered from a low dose of ionizing radiation. Unstable chromosomal aberrations in peripheral blood lymphocytes were investigated in 491 Chernobyl clean-up workers. Information about lifestyle factors (all persons) and medical history (212 persons) was collected. Connections between the rate of chromosomal aberrations and some types of diseases were found. It was also found that Chernobyl clean-up workers with oncological diseases and hypertension had increased rates of chromosomal aberrations. Positive correlations between the grade of hypertension and the level of chromosomal aberrations (r = 0.20, p < 0.01) was revealed. Further investigations need to be carried out in order to understand the mechanisms of this connection.
We conducted a laboratory examination of 83 people after vaccination against the new coronavirus with the use of the ‘Gam-COVID-Vac’ vaccine of National Research Centre for Epidemiology and Microbiology n.a. honorary academician N.F. Gamaleya (Moscow, Russia), in order to determine the presence of post-vaccination class G antibodies to SARS-CoV-2. The reagent system ‘SARS-CoV-2-IgG – ELISA-BEST’ (Vector-Best Co., Novosibirsk, Russia) was used. According to the manufacturer, the reagent system detects a pool of class G immunoglobulins synthesized to all antigenic determinants of protein S, including the RBD domain, which ensures the specificity of this method for assessing the post-vaccination immune response. The study involved 36 men and 47 women, with an average age of 48.40 ± 1.15 years. An interim analysis of the blood serum of 51 participants 21 days after the first dose of the vaccine showed the presence of IgG antibodies to SARS-CoV-2 in 45 (88.24%) people. After 42 days, all 83 (100%) people were found to have IgG antibodies to SARS-CoV-2 virus. It is advisable to continue the study to assess the dynamics of the level of postvaccinal antibodies for 6 months.
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