A 35-year prospective study was undertaken in 126 former college students to determine the predictive value of psychophysiological patterns previously recorded in response to repetitive laboratory stress experiments. Detailed health information has been obtained in 116 (92.1%) of these subjects. The emotion of "severe anxiety" expressed in one or more of the prior tests appeared to be a reliable marker for increased susceptibility not only to coronary heart disease but to overall future illness. This form of pathological anxiety, moreover, was frequently shown to be linked to marked conflict about hostile impulses. Contrariwise, neither anger-in nor anger-out was found to be associated with a higher incidence of subsequent disease. Failure to express emotion was observed in a variety of subjects who as a group exhibited no predisposition to sickness in later life. Psychological Mastery was predictive of favorable prognosis, but Physiological Mastery, contrary to expectations, did not show statistically significant advantages in that regard. Thus, the construct of "Mastery" itself as a determinant of prognosis was not fully supported by the findings in the present study. Cardiovascular hyperreactivity could not be confirmed as a major biologic mechanism responsible for cardiovascular disease. Such hyperresponses were common in association with "anger-in" without evidence of increased susceptibility to cardiovascular disease or other forms of illness. Further research is needed to identify pathophysiological pathways that may be activated by the emotion of severe anxiety in mediating its apparent relationship with total morbidity and mortality over time.
This paper describes a search for weakly or semistrongly interacting particles produced in the collision of 4.9X 10 18 28-GeV protons with a thick copper and brass beam stop. 104 events have been observed; their characteristics are similar to those produced by neutrinos arising from proton interactions in a 15-cm-thick brass target. However, compared to the number expected, an excess of 48 events is found with uncertainties of ± 10 (statistical) and ± 12 (systematic). At most ten events (68% confedence level) are attributable to beam losses.We have searched for directly produced neu-through the use of such a high-density, thick tartrinos, neutrinos from the decay of short-lived get, greatly increasing the likelihood of observ-(< 10" 11 sec) parents, or new penetrating neutral ing promptly produced particles in the detector. particles produced by 28.5-GeV protons from the For the new-particle search, protons were Brookhaven National Laboratory alternating-transported in vacuum to a copper and brass gradient synchrotron (AGS) in a thick copper and beam dump 1.0 m long and 0.3 m 2 in cross secbrass target. Neutral particles were detected in tion followed by a 30-m-long iron absorber. Two our neutrino detector. 1 The flux of neutrinos special runs were made for normalization and from the decay of long-lived mesons is suppressed background measurements. In the normalization 564
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