Vitamins are generally essential; they are mandatory compounds that are not produced in the body and must be taken through food. These compounds, which play a role in enzyme reactions as coenzymes, are indispensable for the human organism. Among them, vitamin D, which is of great importance, can be made in the body differently from others. Vitamin D is a fat-soluble vitamin. Since its chemical structure is similar to steroid hormones and is synthesized in tissue and released into the circulatory system due act on the target tissue, it can also be classified as a hormone. Vitamin D is a fairly important steroid hormone that plays a role in maintaining bone and calcium homeostasis.
Breast cancer is the leading cause of death in women across the globe. The aim of this study is to compare exosomal survivin levels in breast cancer patients and healthy population. It is also to investigate the relationship between clinicopathological parameters of breast cancer and exosomal survivin levels. Patients who were diagnosed with histopathologically confirmed breast cancer and healthy volunteers were included in the study. Serum samples from patients and healthy volunteers were stored at -80℃. Exosomes were isolated from these serum samples. The integrity of the exosomes was disrupted. Survivin levels were measured by Enzyme Linked Immuno Sorbent Assay. Data on clinicopathological parameters were obtained from patient files and compared statistically.
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