Background and objective: In India Medicinal plants have a wide range of uses in folk medical practice. An- drographis macrobotrys Nees. belongs to Acanthaceae family is found in South India and Srilanka. It is in folk use by tribes in Kerala to treat muscle pain, snakebite, fever, and jaundice. The present research work aims to evaluate test drugs for their analgesic action. Methods: The detailed review of the test drug and disease Pain has been carried out. An animal experimental study has been carried out to assess the analgesic activity of the drug by acetic acid- induced writhing movement in Swiss albino mice and Eddy’s hot plate method in Wistar albino rats. Results and conclusion: The test drug showed analgesic action with Swarasa of leaves and Kashaya of the whole plant. The drug was found to have both peripheral and central analgesic action.
Keywords: Andrographis macrobotrys Nees., Acanthaceae, folk medicinal plant, Analgesic action
Background and Objective: Folk medicinal plants are densely found in India which needs to be thorough-ly studied and documented. Andrographis Macrobotrys (Nees) is an erect, stout herb of Acanthaceae fami-ly is used in the treatment of snake bite, diarrhea, muscle pain, fever, jaundice, liver disorders and skin dis-ease by the tribes of Kerala. According to the principles of Ayurveda, basis for use of drug is by analysing its Rasapanchaka (attributes) namely rasa (taste), guna (qualities), vipaka (taste after digestion), virya (po-tency), and prabhava (special action). Hence assessment of Rasapanchaka is necessary for thorough knowledge of the drug. Aim of the present study is to evaluate the Rasa, Guna, Virya, Vipaka and prabha-va of Andrographis Macrobotrys Nees.
Methods: Rasa of whole plant was assessed by direct perception by administering test drug to 25 volun-teers. Virya was assessed by exothermic and endothermic reaction of the drug with water in different con-centrations. Vipaka, guna and prabhava were determined through animal experimental study by adminis-tering drug to 12 Wistar Albino rats.
Result and Conclusion: The assessment of study on rasapanchaka reveals that test drug possess Tiktha (bitter) rasa, Kashaya (astringent) anurasa, laghu (light), ruksha (dry), ushna (hot) guna, katu (pungent) vipaka, sheetha (cold) virya, pachana (digestive), lekhana (scraping) karma (action).
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