On the basis of our results, the transcription of the apoptosis-related gene BCL2L11 is possibly regulated by promoter DNA methylation in ameloblastoma. The biological significance of this finding in ameloblastoma pathobiology remains to be clarified.
The presence of the single nucleotide polymorphisms in exon 1 of the
mannose-binding lectin 2 (MBL2) gene was
evaluated in a sample of 159 patients undergoing coronary artery bypass surgery (71
patients undergoing valve replacement surgery and 300 control subjects) to
investigate a possible association between polymorphisms and heart disease with
Chlamydia infection. The identification of the alleles
B and D was performed using real time polymerase
chain reaction (PCR) and of the allele C was accomplished through
PCR assays followed by digestion with the restriction enzyme. The comparative
analysis of allelic and genotypic frequencies between the three groups did not reveal
any significant difference, even when related to previous Chlamydia
infection. Variations in the MBL plasma levels were influenced by the presence of
polymorphisms, being significantly higher in the group of cardiac patients, but
without representing a risk for the disease. The results showed that despite
MBL2 gene polymorphisms being associated with the protein plasma
levels, the polymorphisms were not enough to predict the development of heart
disease, regardless of infection with both species of Chlamydia.
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