Unusual reactivity of nitroalkanes, involving formation of aci-forms (nitronic acids or nitronates) and their subsequent interaction with carbon-based nucleophiles, is surveyed in this review.
A simple method of calculating the optimum composition of oil and gas condensate feedstock with the easily determined physicochemical properties of its components and standardized performance properties of petroleum products is examined. Key words: crude oil, gas condensate, mixed crude oil and gas condensate, fractionation, optimization of composition.The tendency toward expansion of combined refining of crude oils and gas condensates determines the importance of studying the effect of the composition of the feedstock on the results of the process. The yield of light cuts changes nonadditively when the ratio of the components of the compounded feedstock is changed, and optimization of the composition of such feedstock markedly increases the yield of target cuts and regulates their quality.*The experimental determination of the optimum ratio of feedstock components is laborious and lengthy so that in industrial conditions, crude oil and gas condensate are mixed arbitrarily, oriented toward the maximum acceptable loads in the atmospheric tower and the readings of product quality flow analyzers. We proposed a method for calculating the composition of oil and gas condensate feedstock based on the easily determined physicochemical properties of its components.The potential content of light cuts and the correspondence of their physicochemical properties to the requirements of GOSTs for petroleum products are the basic criteria for the optimality of this feedstock. Rational mixing of the components of the feedstock based on the correspondence of their physicochemical properties to the standardized performance properties of petroleum products is required for increasing the yield and quality of the target cuts.An insufficient reserve for the performance properties of the target cuts in the feedstock will cause production of substandard products and an excess reserve will cause losses of feedstock potential and increase production costs.
The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series of heterocyclic derivatives with a 1,2,3,4-tetrahydropyridine or 1,4,5,6,7,8-hexahydroquinoline fragment. The resulting compounds were tested for analgesic activity in vivo. Some of the prepared compounds showed an antinociceptive effect superior to that of ketorolac in dynamics.
The reaction of 2-amino-1,1,3-tricyanopropene (malononitrile dimer) with
isothiocyanates leads to 1-substituted
4,6-diamino-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitriles or
4,6-diamino-2-(phenylimino)-2H-thiopyran-3,5-dicarbonitrile, depending on the conditions.
Quantum-chemical modeling of the IR spectra and reaction routes for the
synthesized compounds was carried out. In
silico predictive analysis of potential protein targets,
compliance with bioavailability criteria, and ADMET parameters was
performed.
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