Anti-diabetic activity of aqueous fruit extract of Solanum torvum was aimed at detecting the phytochemicals and ascertains the anti-diabetic activity using in vitro experimental models. In this study, physiochemical parameters were carried out and the content of phyto organic constituents such as total alkaloids, flavonoids, phenols, carbohydrates, fats, proteins and crude fiber were determined. LC-MS/MS have been used for detecting the phytochemicals. Different concentrations of the extract have been screened for their anti-inflammatory and antidiabetic activities. Aqueous fruit extract of S. torvum revealed the presence of (iso)pentyl dihexoside, quinic acid derivative, chlorogenic, caffeoylglucaric acid and dicaffeoylquinic acid by LC-MS/ MS analysis. The extract exhibited maximum anti-inflammatory activity of 23.95 % at 1000 µg/ml in inhibition of albumin denaturation, 59.00% at 1000 µg/ml in inhibition of protease denaturation and 64.00% at 1000 µg/ml by HRBC membrane stabilization assay, which are comparable to that of standard aspirin. The extract exhibited maximum anti diabetic activity of 72.00 % at 1000 µg/ml in inhibition of α-amylase activity, 63.00% at 1000 µg/ml in inhibition of α-glucosidase activity and 78.00% at 1000 µg/ml in glucose uptake by yeast cells, which are comparable to that of standard acarbose. From the results, the aqueous fruit extract of S. torvum might possess antidiabetic activity due to the presence of bioactive compounds.
The search for pioneering nutraceuticals from plants is genuine and crucial. Based on the literature review as per Ayurvedic texts, four common plants Capparis spinosa L. (flower buds), Caesalpinia bonducella L.(seeds), Luffa acutangula L.(fruits) and Cassia occidentalis L. (aerial parts) were selected to develop nutraceuticals and were standardized. Based on the nutraceutical and pharmacological efficacies of the individual plant drugs selected, three different herbal nutraceutical formulations were prepared. Nutraceuticals before and after lyophilization were subjected to standardization studies. Nutraceutical formulation 3 developed was found to be best due to its high nutraceutical values when compared to others. Results depicted that up to the dose level of 2000 mg/kg.bw (acute oral toxicity), 1000 mg/kg.bw (sub-acute oral toxicity), it doesn’t produced any lethality in the experimental animals. To conclude that the selected herbal formulation developed from selected plant ingredients was found to possess distinct nutraceutical values. The present work contributes for the development of human healthcare through nutraceutical product with remarkable medicinal properties in herbal way.
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