Immunostimulators are substances that stimulate the immune system by increasing the activity of any of its individual component biological systems. The selected plant species Heterostemma tanjorense Wight &Arn is an area specific medicinal plant. Literature review made on this species reveals not much of its medicinal activity to be explored and documented. The present study reports the immune stimulant activity of Heterostemma tanjorense on azathioprine administered male albino rats. Biological parameters such as RBC, WBC, neutrophils, neutrophil adhesive and immunoglobulins were evaluated and the results were reported.The results obtained were in significant quantities and in reportable amounts.
The present study is to evaluate the antihepatotoxic effect of hydroalcoholic extract of leaf powder of Azima tetracantha and the fruit powder of Tribulus terrestris. Ferrous sulfate was used to induce hepatotoxicity and Silymarin was used as a standard drug. The level of biochemical parameters such as protein, albumin, globulin, HDL, vitamin E, superoxide dismutase and catalase were observed to be decreased and the level of glucose, LDL, VLDL, bilirubin, cholesterol, triglycerides, alkaline phosphatase and TBARS were increased in hepatotoxicity-induced rats. Retrieval of liver parameters to normal level was obtained after the oral administration of herbal drugs. Histopathological studies revealed diminished hepatocellular injury in the herbal drugs treated rats. As a conclusion hydro alcoholic extract of leaf powder of A. tetracantha and fruit powder of T. terrestris were possesses significant hepatoprotective activity.
Anti-diabetic activity of aqueous fruit extract of Solanum torvum was aimed at detecting the phytochemicals and ascertains the anti-diabetic activity using in vitro experimental models. In this study, physiochemical parameters were carried out and the content of phyto organic constituents such as total alkaloids, flavonoids, phenols, carbohydrates, fats, proteins and crude fiber were determined. LC-MS/MS have been used for detecting the phytochemicals. Different concentrations of the extract have been screened for their anti-inflammatory and antidiabetic activities. Aqueous fruit extract of S. torvum revealed the presence of (iso)pentyl dihexoside, quinic acid derivative, chlorogenic, caffeoylglucaric acid and dicaffeoylquinic acid by LC-MS/ MS analysis. The extract exhibited maximum anti-inflammatory activity of 23.95 % at 1000 µg/ml in inhibition of albumin denaturation, 59.00% at 1000 µg/ml in inhibition of protease denaturation and 64.00% at 1000 µg/ml by HRBC membrane stabilization assay, which are comparable to that of standard aspirin. The extract exhibited maximum anti diabetic activity of 72.00 % at 1000 µg/ml in inhibition of α-amylase activity, 63.00% at 1000 µg/ml in inhibition of α-glucosidase activity and 78.00% at 1000 µg/ml in glucose uptake by yeast cells, which are comparable to that of standard acarbose. From the results, the aqueous fruit extract of S. torvum might possess antidiabetic activity due to the presence of bioactive compounds.
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