В процессе двухлетнего наблюдения больных ремиттирующим рассеянным склерозом изучено влияние копаксона на клинические проявления и течение данного заболевания во взаимосвязи с состоянием -. мембрано дестабилизирующих процессов в эритроцитах больных
Ключевые слова:, , . рассеянный склероз копаксон перекисное окисление липидов Twenty three remittent disseminated sclerosis patients have been observed for two years to study the influence of copaxone on clinical manifestations and course of their disease in relation to the state of membrane-destabilizing processes in erythrocytes.
Aim: identification of risk factors of hemorrhagic transformation (HT) after intravenous thrombolytic therapy. Patients and methods: the study included 100 medical records of patients, who underwent thrombolytic therapy. Patients were divided into two groups according to the outcome: 89 patients with HT and 11 patients without HT. Clinical and demographic characteristics of patients were analyzed, including neurological status assessment using NIHSS, Rankin, Rivermead and Waterloo scales. Results: among patients with HT 54.5% were smokers, compared to 29.2% in no HT group (p < 0.05). Significant differences in Rankin, Rivermead and Waterloo scales on admission, after the intervention and at discharge were observed (p < 0.05). Conclusion: smoking is as a significant risk factor of HT, which should be taken into account in the development of thrombolytic therapy programs.
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