No abstract

Self-reported gout is common among patients with CKD and lower GFR is strongly associated with gout. Pharmacological management of gout in patients with CKD is suboptimal. Prospective follow-up will show whether gout and hyperuricaemia increase the risk of CKD progression and cardiovascular events in the GCKD study.

In behavioral tasks, previous research has found that advanced Spanish learners of Dutch rely on duration cues to distinguish Dutch vowels, while Dutch listeners rely on spectral cues. This study tested whether language-specific cue weighting is reflected in preattentive processing. The mismatch negativity (MMN) of Dutch and Spanish participants was examined in response to spectral and duration cues in Dutch vowels. The MMN at frontal and mid sites was weaker and peaked later at Fz for Spanish than for Dutch listeners for the spectrally cued contrasts, whereas both groups responded similarly to the duration cue. In line with overt categorization behavior, these MMN data indicate that preattentive cue weighting depends on the listeners' language experience.

No abstract

In some languages (such as Dutch), speakers produce duration differences between vowels, but it is unclear whether they also encode short versus long speech sounds into different phonological categories. To examine whether they have abstract representations for ‘short’ versus ‘long’ contrasts, we assessed Dutch listeners’ perceptual sensitivity to duration in two vowel qualities: [a] and [ɑ], as in the words maan ‘moon’ and man ‘man,’ which are realized with long and short duration respectively. If Dutch represents this phonetic durational difference as a ‘short’–‘long’ contrast in its phonology, duration changes in [a] and [ɑ] should elicit similar neural responses [specifically, the mismatch negativity (MMN)]. However, we found that duration changes evoked larger MMN amplitude for [a] than for [ɑ]. This finding indicates that duration is phonemically relevant for the maan-vowel that is represented as ‘long,’ while it is not phonemically specified for the man-vowel. We argue that speakers who in speech production distinguish a given vowel pair on the basis of duration may not necessarily encode this durational distinction as a binary ‘short’–‘long’ contrast in their phonological lexicon.

No abstract

Since the presence of major histocompatibility complex (MHC) antigens has recently been reported on murine and human mast cells under various conditions, we have investigated their expression on mast cells in different types of cutaneous inflammation. Cryostat sections from lesional biopsies of patients with psoriasis, atopic eczema, chronic urticaria, lichen planus, bullous pemphigoid and urticaria pigmentosa were immunohistochemically stained with monoclonal antibodies against MHC class I and class II antigens using a double staining APAAP/toluidine blue methodology. While strongly positive staining with the antibody directed against MHC class I antigens was found on nearly all mast cells in normal skin and in inflammatory dermatoses, reactivity for HLA-DR and HLA-DQ antigens on mast cells could not be detected, except for less than 2% of cells with doubtful staining. Human mast cells therefore probably play no significant rôle as antigen-presenting cells in the conditions studied.

The effect of isoproterenol (IPR) on bone-marrow cAMP content was investigated in vivo and in vitro. In unirradiated CFW mice, the bone-marrow cAMP content was found to be elevated by the administration of noradrenaline, adrenaline and isoproterenol. After IPR administration, the increase in cAMP was biphasic with maxima at 1 and 15 min. An increase in cAMP content was also noted in bone-marrow of sublethally-irradiated mice, but no further increase was observed 15 min after the administration of IPR. Elevation of cAMP by either IPR or radiation was prevented by pretreatment with the beta-adrenergic blocking agent--propranolol. IPR was also effective in increasing the cAMP content when added to suspension of bone-marrow cells. This effect was abolished by propranolol. IPR did not increase cAMP levels in bone-marrow cells isolated from irradiated animals. The results suggest that the differentiated bone-marrow cells have beta-adrenergic receptors.