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The general requirements for joint replacement devices emphasizes the importance of device material biocompatibility, with no inflammatory or toxic response to wear beyond a tolerable level, the appropriate mechanical properties for the desired application, and lastly economically viable manufacturing and processing methods. Implicit in these requirements is the importance of understanding wear and failure mechanisms of implanted devices. However, compared to orthopedic total joint replacement (TJR) devices, functional wear failure mechanisms for temporomandibular joint (TMJ) TJR implants have not been clearly defined. Our research group has started initial translational investigations involving the analysis of failed retrieved TMJ TJR devices alloy microstructure compared to control, never implanted, TMJ TJR devices utilizing established orthopedic TJR device retrieval tribocorrosion evaluation protocols. This and future studies will guide future material choices and functional design improvements for TMJ TJR devices. Orthopedic TJR implant schemes may also be improved by understanding the degradation mechanism of TMJ TJR implants, as the materials employed in both TJR devices are similar.