The results obtained from the present study suggest that complement mediated solubilization is less in patients with tuberculosis, and this defective solubilization is likely to take part in a vicious cycle involving immune complex deposition and complement activation and, thus, may lead to disease progression depending on the nature of the defect.
High-grade PanIN-3 lesions showed significant association with pancreatic malignancy. Obstructive jaundice and CA 19-9 ≥ 137.5 could predict PanIN positivity.
Background: Aim and objectives was to study clinical profile of patients with severe alcoholic hepatitis (SAH) and evaluate clinical factors associated with short term (30-day) mortality. Osmania General Hospital. This study was approved by ethics committee of the hospital and written informed consent was obtained from all subjects included in the study. Patients with clinical alcoholic hepatitis with serum bilirubin >5mg/dl, aspartate amino transferase (AST)/ alanine amino transferase (ALT) ratio >2 with an AST level >45 but <500U/L, Maddrey's Discriminant function (MDF) ≥32 were included in the study. Results: The 30-day mortality of severe AH in the current study was 40%. Alcoholic hepatitis was most common in males between 40-50 years with a median age of 46.9±7.7 (31-60) years. The clinical complications consisted of hepatic encephalopathy (HE) in 40%, hepato renal syndrome (HRS) and renal failure in 18.2% and infections in 40%. HRS, bilirubin, ALT, AST, urea, creatinine, Na+ and all prognostic scores showed significant association with in hospital mortality at 30days on univariate analysis while United Kingdom end liver disease (UKELD) and Child-Turcotte-Pugh (CTP) scores showed most significance on multivariate regression analysis. Conclusions: The 30-day mortality of severe AH in the current study was 40%. High UKELD, CTP scores and presence of HRS/Renal dysfunction at time of admission are associated with high 30-day mortality. Patients with advanced age, decompensated cirrhosis, coagulopathy, renal injury, malnourished status and low sodium respond poorly to therapy.
BACKGROUNDAlcoholic Liver Disease (ALD) includes a wide range of injury from reversible steatosis, steatohepatitis to irreversible cirrhosis. Alcoholic hepatitis is a very important entity, because severe alcoholic hepatitis is associated with a high short term mortality rate of 40-45%, which is unacceptable and has to be prevented. So far the severity of alcoholic hepatitis is identified by calculating 'Modified Discriminant Function' (mDF) score. This score includes only Prothrombin Time (PT) and bilirubin in calculating the severity of alcoholic hepatitis. MDF of greater than or equal to 32 is considered severe and treated with steroids and pentoxifylline. New scoring system 'Glasgow Alcoholic Hepatitis Score (GAHS) which includes age, white cell count, urea, PT and serum bilirubin level is used in identifying the patients in need of drug therapy.
This study is to analyse the Publications in the Journal of Addictive behaviors during the period of 2013-2017 PubMed databases. During this period from 2013 to 2017 article contribution gradually increased then decreased in a same way. Year wise article publication was analyzed. In 2015, 160 (24.88%) articles were published and in 2017 only 71(11.04%) were published. During this period single author contribution was very less 5 (0.77%) and Multiauthored contributed was high 638 (99%). Degrees of collaboration were analyzed to calculate collaboration between single & multi author contribution. Cumulative growth also analyzed during this period.
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