No abstract

A large number of papers have reported that administration of n-3 FA reduced serum TG concentrations in hypertriglyceridemic patients. However, few studies have examined the effect of n-3 FA on serum concentrations of remnant-like particle (RLP) cholesterol. Volunteers (n = 41) whose serum TG concentrations were 100-300 mg/dL were recruited and randomly assigned to either an n-3 FA group or a control group with stratification by sex, age, and serum TG level in a double-blind manner. The subjects in the n-3 FA group were administered 125 mL of fermented soybean milk with fish oil containing 600 mg of EPA and 260 mg of DHA/d for 12 wk. The controls consumed control soybean milk with olive oil. Fasting blood samples were obtained before the start of administration and at 4, 8, and 12 wk. EPA concentrations in red blood cells increased significantly in all but one subject in the n-3 FA group, with no significant changes in the control group. TG levels decreased more in the n-3 FA group than in the control group at weeks 4 (P < 0.05), 8 (P < 0.01), and 12 (P < 0.05) with their baseline as covariate. RLP cholesterol levels decreased more in the n-3 FA group than in the control at weeks 8 (P < 0.01) and 12 (P < 0.05) with their baseline as covariate. The groups did not differ in the other lipid levels. It is likely that n-3 long-chain FA may exert anti-atherosclerotic effects by lowering serum TG and RLP-cholesterol levels even at the dose of 860 mg/d.

A lipid emulsion containing PGE1 within its lipid particles (Lipo-PGE) is expected to repected PGE1 gradually from the lipid particles in clinical application. In medical practice, Lipo-PGE is generally applied after being diluted with infusion fluids. PGE1 is thus thought to be released rapidly from the lipid particles to the aqueous phase when Lipo PGE1 is diluted with infusion fluids. We have kinetically studied the release of PGE from both the Lipo-PGE and PGE1 solution as a control, while varying both the quantity of the diluting fluid and the temperature. We kinetically simulated the release of PGE1 from the lipid particles of Lipo-PGE. As a result, that Lipo-PGE was thus suggested to release PGE1 from the lipid particles rapidly after dilution.

No abstract

Eight Holstein steers 4.5 months, on the average, of age were divided equally into two groups. In each animal of one group, 2 pellets of a zeranol