Ensemble-averaged statistics at constant phase of the turbulent near-wake flow (Reynolds number ≈ 21400 around a square cylinder have been obtained from two-component laser-Doppler measurements. Phase was defined with reference to a signal taken from a pressure sensor located at the midpoint of a cylinder sidewall. The distinction is drawn between the near wake where the shed vortices are ‘mature’ and distinct and a base region where the vortices grow to maturity and are then shed. Differences in length and velocity scales and vortex celerities between the flow around a square cylinder and the more frequently studied flow around a circular cylinder are discussed. Scaling arguments based on the circulation discharged into the near wake are proposed to explain the differences. The relationship between flow topology and turbulence is also considered with vorticity saddles and streamline saddles being distinguished. While general agreement with previous studies of flow around a circular cylinder is found with regard to essential flow features in the near wake, some previously overlooked details are highlighted, e.g. the possibility of high Reynolds shear stresses in regions of peak vorticity, or asymmetries near the streamline saddle. The base region is examined in more detail than in previous studies, and vorticity saddles, zero-vorticity points, and streamline saddles are observed to differ in importance at different stages of the shedding process.
The nasal cavity is the main passage for air flow between the ambient atmosphere and the lungs. A preliminary requisite for any investigation of the mechanisms of each of its main physiological functions, such as filtration, air-conditioning and olfaction, is a basic knowledge of the air-flow pattern in this cavity. However, its complex three-dimensional structure and inaccessibility has traditionally prevented a detailed examination of internal in vivo or in vitro airflow patterns. To gain more insight into the flow pattern in inaccessible regions of the nasal cavity we have conducted a mathematical simulation of asymmetric airflow patterns through the nose. Development of a nose-like model, which resembles the complex structure of the nasal cavity, has allowed for a detailed analysis of various boundary conditions and structural parameters. The coronal and sagittal cross-sections of the cavity were modeled as trapezoids. The inferior and middle turbinates were represented by curved plates that emerge from the lateral walls. The airflow was considered to be incompressible, steady and laminar. Numerical computations show that the main air flux is along the cavity floor, while the turbinate structures direct the flow in an anterior-posterior direction. The presence of the turbinates and the trapezoidal shape of the cavity force more air flux towards the olfactory organs at the top of the cavity.
Ischemic heart diseases put a heavy economical burden on Western society. They remain one of the major causes of morbidity, and preventive or postoperative treatments are lengthy and expensive. In some patients of ischemic heart diseases, there is not a direct correlation between the degree of occlusion of major arteries and the development of medical symptoms or damage to the heart function. Interestingly, these patients develop well-formed collateral vessels that compensate for the decrease in blood supply to the heart wall. Clearly, the ability to understand why and how these patients develop collateral vessels may serve as a base for a new strategy to treat ischemic heart diseases by promoting collateral formation. The current article summarizes recent advances in the understanding of how collateral vessels develop and offers the authors' point of view on the central role of biomechanical forces in this process and the molecular mechanisms that underline it.
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