Hemodynamic Forces as a Stimulus for Arteriogenesis

Resnick, Nitzan; Einav, S.; Chen-Konak, Limor; Zilberman, Michal; Yahav, Hava; Shay-Salit, Ayelet

doi:10.1080/713715231

Cited by 17 publications

(13 citation statements)

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“…A large body of evidence demonstrates the influence of WSS on vascular endothelial cells as well as on vascular smooth muscle cells 2,9,30 resulting in as different events as flow-mediated vasodilatation, atherosclerosis, thrombus formation, and vascular remodelling. Additionally to the time-averaged WSS, other hemodynamic parameters of the near wall flow have been proposed for clinically oriented flow studies: the oscillatory shear index (OSI), the time-averaged wall shear stress gradient (both spatial (WSSG s ) and temporal (WSSG t )), the wall shear stress angle deviation (WSSAD), and the wall shear stress angle gradient (WSSAG).…”

Section: Hemodynamic Parameters and Their Link To Biological Aspectsmentioning

confidence: 99%

“…The pattern of this distribution corresponds to zones of disturbed flow with vortex formations and low-velocity flow in coronary vessels. 12 A large body of evidence demonstrates the influence of wall shear stress (WSS) on vascular endothelial cells as well as on vascular smooth muscle cells, 2,9,30 resulting in different events such as flow mediated vasodilatation, atherosclerosis, and vascular remodelling. Therefore three-dimensional (3D) reconstruction of the geometry and the prediction of biofluidmechanical properties based on CFD modelling may help to assess the local risk in coronary artery segments prone to early atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

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Coronary Artery WSS Profiling Using a Geometry Reconstruction Based on Biplane Angiography

et al. 2009

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Computational fluid dynamics (CFD) methods based on three-dimensional (3D) vessel reconstructions have recently been shown to provide prognostically relevant hemodynamic data. However, the geometry reconstruction and the assessment of clinically relevant hemodynamic parameters may depend on the used imaging modality. In this study, the silicon model of the left coronary artery (LCA) was acquired with a biplane angiography. The geometry reconstruction was done using commercial CAAS 5.2 QCA 3D software and compared with an original geometry. The original model is an optically digitized post-mortem vessel cast. The biplane angiography reconstruction achieved a Hausdorff surface distance of 0.236 mm to the original geometry that is comparable with results obtained in our earlier study for computed tomography (CT) and magnetic resonance imaging (MRI) reconstructions. Steady flow simulations were performed with a commercial CFD program FLUENT. A comparison of the calculated wall shear stress (WSS) shows good correlation for histograms (r=0.97) and good agreement among the four modalities with a mean WSS of 0.65 Pa in the original model, of 0.68 Pa in the CT-based model, of 0.67 Pa in the MRI based model, and of 0.69 Pa in the biplane angiography-based model. We can conclude that the biplane angiography-based reconstructions can be used for the WSS profiling of the coronary arteries.

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Section: Hemodynamic Parameters and Their Link To Biological Aspectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Coronary Artery WSS Profiling Using a Geometry Reconstruction Based on Biplane Angiography

et al. 2009

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“…In such a case we solve the governing equation for the integrated pressure (19) with boundary conditions q y = −ū 2 tan(α 1 )H(x) at y = 0+, −ū 2 tan(α 2 )H(x) at y = 0−. (27) where α 1 and α 2 are the divergent angles of the upper and lower daughter respectively (with symmetric branching implying α 2 = −α 1 ), both of which are assumed to lie below the second critical value as described in [36]; the usual boundary conditions of q → 0 as x → −∞ and as r → 1− also apply. The general solution in the upstream mother tube thus includes both symmetric and antisymmetric parts, and takes the form…”

Section: Shape-driven Flowsmentioning

confidence: 99%

“…Branch-junction sites are medically important for flow blockage and disease initiation [4,26,25,35,12,27,3]. They significantly influence cardiovascular performance in the human torso and cerebrovascular effects in the head.…”

Section: Introductionmentioning

confidence: 99%

Non-symmetric branching of fluid flows in 3D vessels

Ovenden

Smith

2018

ANZIAMJ

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Nonsymmetric branching flow through a three-dimensional vessel is considered at medium-to-high flow rates. The branching is from one mother vessel to two or more daughter vessels downstream, with laminar steady or unsteady conditions assumed. The inherent three-dimensional nonsymmetry is due to the branching shapes themselves, or the differences in the end pressures in the daughter vessels, or the incident velocity profiles in the mother. Computations based on lattice-Boltzmann methodology are described first. A subsequent analysis focuses on small three-dimensional disturbances and increased Reynolds numbers. This reduces the three-dimensional problem to a two-dimensional one at the outer wall in all pressure-driven cases. As well as having broader implications for feeding into a network of vessels, the findings enable predictions of how much swirling motion in the cross-plane is generated in a daughter vessel downstream of a three-dimensional branch junction, and the significant alterations provoked locally in the shear stresses and pressures at the walls. Non-uniform incident wall-shear and unsteady effects are examined. A universal asymptotic form is found for the flux change into each daughter vessel in a three-dimensional branching of arbitrary cross-section with a thin divider.

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“…Gene expression of endothelial nitric oxide synthase (eNOS) was also increased by the second day (82). VEGFR2, an endothelial cell receptor for VEGF, acts as a shear stress sensor and transduces the signal of a change in blood flow (83). Conduit artery modification occurs in response to localized short term resistance exercise training secondary to altered shear stress (67).…”

Section: Arteriogenesis Shear Stress and Exercisementioning

confidence: 99%

Flow mediated vasodilation changes in older and younger adult groups after 4 weeks of low intensity hand grip isometric training with vascular occlusion

Severin

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Hemodynamic Forces as a Stimulus for Arteriogenesis

Cited by 17 publications

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Coronary Artery WSS Profiling Using a Geometry Reconstruction Based on Biplane Angiography

Coronary Artery WSS Profiling Using a Geometry Reconstruction Based on Biplane Angiography

Non-symmetric branching of fluid flows in 3D vessels

Flow mediated vasodilation changes in older and younger adult groups after 4 weeks of low intensity hand grip isometric training with vascular occlusion

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