Diallyl disulfide (DADS) is a garlic-derived organo-sulfur compound. This study was carried out to investigate the protective potential, antioxidant, and anti-inflammatory effects of this compound against cyclophosphamide (CP)-induced hepatotoxicity in rats. A single intraperitoneal dose of CP (200 mg/kg) resulted in a significant disturbance in hepatic function and oxidative stress, as well as inflammatory biomarkers. In addition, histopathological examination showed distinct changes and increased expression of proliferating cell nuclear antigen in hepatocytes. On the other hand, daily oral preadministration of DADS (200 mg/kg) for 10 days before the CP dose effectively attenuated the hepatotoxicity caused by CP administration as confirmed by significant amelioration of the aforementioned parameters in rat’s liver. It could be concluded that administration of DADS can diminish CP-induced hepatotoxicity through concurrent upregulation of antioxidant and anti-inflammatory responses that denote its possible potential clinical application against side effects of the CP drug.
The biological effects of low doses of gamma radiation on full grown male and female pupae of the black cut worm, Agrotis ipsilon (Hufn.) concerning their (P1) generation and its influence on their first (F1) generation were studied.The results confirmed that, the average number of eggs of the parental generation (P1 ) was significantly reduced when both sexes were exposed to 100 and 150 Gy. The highest reduction was clearly observed in P1 female. However, on exposing both sexes to 50 Gy, results showed that, the average number of eggs was not significantly affected in case of full grown male pupae, while it was significantly reduced in case of irradiated full grown female pupae in comparison to the untreated control.Results also showed that the percentage of egg hatch of P1 generation was gradually reduced by increasing the irradiation dose in both the full grown male and female pupae. This reduction was significant at 50, 100 and 150 Gy in case of P1 female generation and at 100 and 150 Gy in case of P1 male generation in comparison to the untreated control as the percentage of egg hatch was not significantly reduced at 50 Gy for P1 male. The results on mating ability through the P1 generation showed that irradiation of males and females by low doses of gamma rays at 50 and 100 Gy did not clearly affect the percentage of mating at any of the tested doses.While the percentage of mating clearly reduced at 150 Gy in both sexes. Results also showed that, the average number of spermatophores per mated female was decreased by increasing the dose to parental males.The Percentage of F1 progeny survived to adult stage was reduced at 50 Gy and the reduction increased by increasing the dose of irradiation. The average larval duration seemed to be about the control in the progeny of the 50 Gy, while the average larval duration increased at 100 and 150 Gy compared to their control treatment. The average pupal duration seemed to be about the control in the progeny of the 50 Gy, while the average pupal duration at 100 and 150 Gy was clearly affected compared to the control treatment. The percentage of pupation seemed to be about normal at 50 Gy, while it was reduced at 100 and 150 Gy, respectively. The percentage of adult emergence decreased with increased irradiation dose. The sex ratio among the progeny of irradiated males seemed to be skewed some what to male side especially at 100 and 150Gy
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.