Chronic treatment with non-steroidal anti-inflammatory drugs such as acetylsalicylic acid may cause a number of adverse effects and chronic conditions. Intestinal adsorbents based on natural materials are used to prevent or treat various intoxications. In this study, it was described detoxification and protective effect of composite pectin/montmorillonite intestinal adsorbents in rats receiving high doses of acetylsalicylic acid. 60 Wistar rats received 100 mg/kg of acetylsalicylic acid without or together with composite intestinal adsorbents based on montmorillonite and 5%, 10%, and 20% pectin. After 16 days of the experiment, blood samples were collected to measure blood biochemistry profiles, including levels of total protein, albumin, glucose, cholesterol and liver enzymes. It was observed significant changes in blood biochemistry profile as well as in liver enzyme levels in rats receiving acetylsalicylic acid for 16 days. Concomitant administration of acetylsalicylic acid and composite intestinal adsorbents based on montmorillonite and 5%, 10%, and 20% pectin provided a protective effect as judged by recovery of blood biochemistry and liver enzyme profiles to control levels. The composite adsorbent with 20% pectin had maximum effect. Therefore, pectin/montmorillonite intestinal adsorbents can be used to decrease gastrointestinal irritation and adverse effects of drugs, such as acetylsalicylic acid.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.