The title compound, [Rh(η5-C5Me5)Cl(C13H12ClN3)]Cl, is chiral at the metal and crystallizes as a racemate. Upon coordination, the hydrazinylidenepyridine ligand is non-planar, an angle of 54.42 (7)° being observed between the pyridine ring and the aromatic ring of the [2-(4-chlorophenyl)hydrazin-1-ylidene]ethyl group.
Second-order rate constants of the reactions of p-toluenesulfonyl chloride with p-substituted benzoic acids in the presence of triethylamine in acetonitrile/acetone under equimolar and pseudo-first-order conditions have been determined by the conductometric method using the Guggenheim principle at 25, 30, 35, and 40 • C. The reactions follow second order with respect to the whole and first order with respect to each of the reactants. The order of reactivity of the substituents in benzoic acid is rationalized. Activation parameters are obtained by applying the usual methods. The Hammett plot has been found nonlinear, whereas the Bronsted plot shows good correlation. This may be explained on the basis of electronic effects of substituents on the reaction center. Kinetic data and the product analyses indicate that the reaction proceeds through direct nucleophilic attack on the sulfur center.
Tosyl ester(s) of α-hydroxy acid(s) were prepared by treating the acid with p-toluenesulfonyl chloride (TsCl) in the presence of pyridine. The products were isolated, identified by TLC and characterized by IR, 1 H-NMR and 13 C-NMR spectral techniques. Anti microbial activity of the synthesized compounds were studied by Agar well diffusion method against two bacterial (Escherichia Coli and Staphylococus Aureus) and two fungal (Candida albicans and Aspergillus Niger) species using Ciprofloxacin against the bacterial strains, Nystatin against Candida albicans and Amphotericin against Aspergillus niger as standard antibiotics. The results infer that the tosyl ester(s) of αhydroxy acid(s) are potentially active against bacterial and fungal strains.
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