The article comprises a set of theoretical and practical suggestions about the development of regional innovation system in the Republic of Tatarstan and realization of regional innovation policy according to strengths and weak of the environment. To understand the opportunities and threats toTatarstan innovation system comparative analysis with Volga federal district regions was hold. As a result the overall ranking of Volga federal district regions was made. Further improvement of Tatarstan innovation system was described by SWOT-analysis.
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