The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model. The KT sample (KT4) produced by fermenting BT for four days, showed the best DPPH radical scavenging capacity and phenolics contents. Hence the ulcer-healing activity of KT4 was compared with those of CT4 and BT. All the tea extracts (15 mg kg(-1)) could effectively heal the gastric ulceration as revealed from the histopathological and biochemical studies, with relative efficacy as KT4 > CT4 ∼ BT. The healing capacities of the tea extracts could be attributed to their antioxidant activity as well as the ability to protect the mucin content of the gastric tissues. In addition, the ability of KT4 to reduce gastric acid secretion might also contribute to its ulcer-healing activity. The tea preparation KT4 (15 mg kg(-1)) was as effective as the positive control, omeprazole (3 mg kg(-1)) in ulcer healing.
From the aerial parts of PHYLLANTHUS NIRURI L. (Euphorbiaceae) plant two alkaloids 4-methoxy-securinine (phyllanthine) ( 1) and 4-methoxy-nor-securinine ( 2) have been isolated and their structures elucidated on the basis of spectroscopic data. The former alkaloid is isolated for the first time from this plant and the latter is a new alkaloid.
6,7-Dehydroroyleanone (12-hydroxyabieta-6,8,12-trien-1 1, 14-dione) (1) has been isolated for the first time from the roots of Salvia moorcraftiana wall. (Labiatae) and identified on the basis of its spectroscopic and chemical analysis.
Synthesis of enantiopure pheromones I and II, both of them bearing chiral methyl branching and an α-oxygenated carbon centre, has been accomplished using compound 2 prepared from D-mannitol as the chiral precursor.
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