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Social support (SS) from parents and peers are key reinforcing factors in the Youth Physical Activity Promotion (YPAP) model. This study aims to identify the relative contribution of parental and peer SS on youth participation in moderate to vigorous physical activity (MVPA). Participants included 203 high school students (n = 125 girls; mean age 14.99 ± 1.55 years). MVPA was assessed by accelerometry. SS influences were evaluated using a well-established scale. Structural equation modeling measured (AMOS, Version 19) the relative fit of the YPAP models using both parental and peer SS. Parental SS had significant associations with both predisposing factors, enjoyment (β = .62, p < .01), and self-efficacy (β= .32, p < .01), as well a direct effect on MVPA (β = .30, p < .01). Peer SS had direct effect on MVPA (β = .33, p < .05), also significantly influenced levels of enjoyment (β = .47, p < .01) and self-efficacy (β = .67, p < .01). In both models self-efficacy mediated the influence on MVPA. The direct effects for parents and peers were similar. This demonstrates that both parental and peer social support exert a strong influence on adolescent MVPA.

Background: The indoleamine 2,3-dioxygenase (IDO) pathway is a key counter-regulatory mechanism that normally inhibits immune responses when appropriate. In the setting of cancer, IDO pathway-mediated immune suppression is exploited by tumors in order to prevent and defeat anti-tumor immunity. Small-molecule inhibitors of the IDO pathway, such as indoximod, are an increasingly validated class of potential cancer therapeutics. Additionally, pre-clinical tumor models have shown complementary effects with indoximod / anti-PD1 checkpoint inhibitor treatment combinations. A clinical trial was developed based upon these data. Methods: Upon successful completion of a Phase 1b dose escalation cohort, metastatic melanoma patients were enrolled in a single arm Phase 2 trial evaluating the addition of indoximod to standard of care checkpoint inhibitors approved for melanoma. Treating physicians were allowed to administer their choice of approved checkpoint inhibitor. The large majority of patients received indoximod with pembrolizumab and this interim report is limited to those patients. Indoximod was administered continuously in 21 days cycles (1200mg po twice daily) concurrently with pembrolizumab (3mg/kg q21 days). Study endpoint is best overall response (objective response rate (ORR) = complete response rate (CR) + partial response rate (PR)) per site reported RECIST criteria. Results: At time of data cut-off, 60 patients had received indoximod /pembrolizumab and were evaluable for response, defined as having at least one follow-up imaging study performed. The ORR was 52% (31/60) with a CRR of 8% (5/60). The combination was well tolerated. The most frequently reported adverse events (regardless of attribution), occurring in ≥ 20% of subjects, were fatigue, diarrhea, nausea, arthralgia, headache, cough, rash, pruritus, and hypertension. The most frequently reported laboratory abnormalities (regardless of attribution), were anemia (17%) and hyperglycemia (17%). Conclusions: The interim analysis of the combination of indoximod and pembrolizumab demonstrates an ORR of 52% which compares favorably with the established ORR for pembrolizumab alone. Updated data to be presented. NCT02073123. Citation Format: Yousef Zakharia, Robert McWilliams, Monaster Shaheen, Kenneth Grossman, Joseph Drabick, Mohammed Milhem, Olivier Rixie, Samir Khleif, Ryan Lott, Eugene Kennedy, David Munn, Nicholas Vahanian, Charles Link. Interim analysis of the Phase 2 clinical trial of the IDO pathway inhibitor indoximod in combination with pembrolizumab for patients with advanced melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr CT117. doi:10.1158/1538-7445.AM2017-CT117

Using a sample of 13,500 adolescents (53% female and 47% male) who participated in all four waves of the National Longitudinal Study of Adolescent Health, this study used multilevel regression to examine the influence of early structural community adversity (as measured by rates of community poverty, single-parent headed families, and two indicators of employment) and racial/ethnic status on cardiovascular disease (CVD) risk factors of young adults (systolic blood pressure, diastolic blood pressure, and mean arterial pressure). The moderating role of youth's socioeconomic attainment was also examined. Results indicate that early community adversity and African American racial status place young adults at risk for CVD. Youth's socioeconomic attainment does not erase the persistent influences of early community adversity and African American racial status on CVD risk. However, the level of education attained can protect African American young adults and those experiencing early community adversity from CVD risk factors.

Background:If the Youth Physical Activity Promotion (YPAP) model adequately explains youth physical activity (PA) in 2 different cultures and with 2 different sets of instruments, it would suggest that the model has broad utility for youth activity promotion.Methods:Two samples from different countries were used: sample 1—USA, 159 students (n = 83 girls) mean age 11.52 ± 1.40 years; sample 2—Portugal, 203 students (n = 125 girls) mean age 14.99 ± 1.55 years. PA was assessed by accelerometry. The YPAP model was analyzed through structural equation modeling using AMOS (version 17.0).Results:In sample 1, social-support had a direct association on MVPA (β = .58, P < .001), enjoyment (β = .70, P < .05), and self-efficacy (β = –.66, P < .001). Enjoyment significantly predicted MVPA (β = .60, P < .001) and self-efficacy significantly predicted MVPA (β = .55, P < .001). In sample 2, social-support had a direct effect on MVPA (β = .33, P < .05), significantly predicted enjoyment (β = –.43, P < .001), and significantly predicted self-efficacy (β = .63, P < .001). Self-efficacy was a significant predictor of MVPA (β = .14, P < .001) but enjoyment was not.Conclusions:Differences were noted in the nature of the relationships and the relative importance. Self-efficacy and social support had significant effects on MVPA in both samples—despite differences in the way that they were measured and operationalized.