Objective: Little research has been undertaken regarding the
psychological impact of cancer on those stricken during the young adult
years. Specifically, research on the coping strategies of young adults
with cancer is limited.Method: In this qualitative, Grounded Theory study, we did
not set out to examine coping; rather, it emerged as a major phenomenon in
the analysis of interview data from 15 young adults with cancer.Results: These young adults used various coping strategies to
come to terms with the cancer diagnosis, management of the illness, its
treatment, and treatment sequelae. The coping strategies varied
considerably from person to person, depended on the stage(s) of the
illness, and were rooted in their precancer lives. We were able to discern
a pattern of coping strategies used by most participants. The prevailing
goal for all participants was to achieve what they called
“normalcy.” For some, this meant major changes in their lives;
for others it meant to “pick up” where they had left off
before the cancer diagnosis.Significance of results: To aid the understanding of the
issues that influence coping, we have developed a model to illustrate the
bidirectional nature and the complexities of the coping strategies as they
relate to the phases of the disease and the disease treatment. The model
also affirms Folkman and Lazarus' coping theory.
ObjectiveIn a study conducted in New Brunswick and Newfoundland and Labrador, we examined the economic impact on families caring for a child with cancer.
MethodsWe undertook semi-structured interviews with 28 French and English families with a child diagnosed with cancer in the last 10 years.
Widespread silence around cancer reflects both the limited access First Nations people have to formal, supportive programs and services, as well as the creative ways they provide emotional, social, and financial support within their informal networks. Beyond the support of their communities, they also required institutional provision of care that is culturally safe, addressing the colonial impacts on cancer communication and the disproportionate burdens of disease in First Nations communities.
miRNAs (miRs), or small approximately 22-nucleotide-long single-stranded noncoding RNA molecules, interact with 3' untranslated regions of target mRNAs, leading to inhibition of protein production. miR-214 is often dysregulated in various cancers, which governs both tumorigenic and tumor suppressive functions. This review focuses on the current knowledge of miR-214 switching in diverse forms of cancer either by its upregulation or downregulation and sheds light on the mechanism of its tumorigenic and suppressive roles. This article describes known targets and signaling pathways that impact tumorigenesis and tumor suppression and summarizes all information available on circulating levels of miR-214 to address whether miR-214 may function as a potential biomarker and therapy for cancer patients in the future.
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