A new paper-based analytical device design was fabricated by wax printing method for simultaneous Cu(II), Co(II), Ni(II), Hg(II), and Mn(II) determination. Colorimetry was used to quantify the heavy metal ions,...
Capillary forces
are commonly employed to transport fluids in pump-free
microfluidic platforms such as paper-based microfluidics. However,
since paper is a porous material consisting of nonuniform cellulose
fibers, it has some limitations in performing stable flow functions
like mixing. Here, we developed a pump-free microfluidic device that
enables rapid mixing by combining paper and plastic. The device was
fabricated by laminating transparency film and double-sided adhesive
and is composed of an overlapping inlet ending in a paper-based reaction
area. The mixing performance of the developed device was confirmed
experimentally using aqueous dyes and pH indicators. In addition,
the absolute mixing index was evaluated by numerically calculating
the concentration field across the microfluidic channels. To demonstrate
the utility of the new approach, the detection of an organophosphate
pesticide was carried out using a colorimetric enzymatic inhibition
assay. The developed device and a smartphone application were used
to detect organophosphate pesticide on food samples, demonstrating
the potential for onsite analysis.
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