This is a PDF file of a peer-reviewed paper that has been accepted for publication. Although unedited, the content has been subjected to preliminary formatting. Nature is providing this early version of the typeset paper as a service to our authors and readers. The text and figures will undergo copyediting and a proof review before the paper is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.

AbstractOne of the key challenges in biology is to understand how individual cells process information and respond to perturbations. However, most of the existing single-cell analysis methods can only provide a glimpse of cell properties at specific time points and are unable to provide cell secretion and protein analysis at single-cell resolution. To address the limits of existing methods and to accelerate discoveries from single-cell studies, we propose and experimentally demonstrate a new sensor based on bound states in the continuum to quantify exosome secretion from a single cell. Our optical sensors demonstrate high-sensitivity refractive index detection. Because of the strong overlap between the medium supporting the mode and the analytes, such an optical cavity has a figure of merit of 677 and sensitivity of 440 nm/RIU. Such results facilitate technological progress for highly conducive optical sensors for different biomedical applications.

We computationally study periodic impedance-matched metal-dielectric metamaterials and the advantage of imprinting moth-eye surfaces on them. Impedance-matched metamaterials are known to act as strong, polarization-independent, broadband absorbers. However, in the infrared region far from the metal's plasma frequency, the reflection from metal layers dominates over the absorption. Using anti-reflective moth-eye surfaces we show that it is possible to obtain absorption independent of polarization or incidence angle, over an exceptionally broad frequency range from 400 nm to 6 μm.

In this Letter, we present a design strategy for the realization of electrically powered bound states in the continuum (BIC) lasers. Despite growing attention of the optics community for BICs, practical uses of BICs in an active device are still unestablished. A large index contrast and out-of-plane symmetries that aid the formation of BICs are not trivial to achieve using conventional approaches for semiconductor laser design. Here, we propose a doping scheme to circumvent this issue. We also show that the introduction of material absorption due to carriers deteriorates the quality factor of BIC modes and show that a suitable compromise between electrical conductivity and optical loss can be achieved.

No abstract

No abstract

No abstract

No abstract