Aceclofenac is a potent anti-inflammatory analgesic agent indicated for acute and chronic treatment of rheumatoid arthritis, ostio arthritis, and onkylosing spondylytis. Aceclofenac is poorly water soluble and may show dissolution limited absorption. Solid dispersions (SDs) of Aceclofenac in PEG-6000, PVP were prepared by solvent evaporation method. The solid dispersion was characterized for physical appearance, solubility and IR. FTIR study reveled that drug was stable in SDs. Solubility of Aceclofenac from SDs increased in distilled water. The drug content was found to be high and uniformly distributed in the all formulation. Dissolution of drug increased from all the solid dispersion. Dissolution of Aceclofenac increased with increase in the proportion of carriers (1:1, 1:5, and 1:9). Of both the carriers used, dissolution of the drug was more in PEG 6000 based SDs. It is concluded that dissolution of the Aceclofenac could be improved by solid dispersion and PEG 6000 based solid dispersions were more effective in the enhancing the dissolution.
Context: Humic acid (HA), a naturally occurring chemical compound, is now being studied for medicinal applications. Paclitaxel (PTX), a strong anticancer agent, has a low water solubility, resulting in limited bioavailability following oral administration, improper tissue localisation, and poor therapeutic use. The goal of this study is to see if PTX can be complexed with HA to improve its solubility and bioavailability effectiveness. Materials and procedures: Differential scanning calorimetry, Fourier Transform Infrared spectroscopy, X-ray diffraction, and scanning electron microscopy were used to analyse complexes produced by solvent evaporation in varied weight ratios. Conclusion: Using HA to enhance the solubility and bioavailability of medicines is a beneficial method.
Ever since herbs were used from the ancient ages to treat various diseases in one or the other form of drugs for the betterment of mankind. Due to this usage slowly the verge cam e to a decline or over exploitation which resulted in decrease of production of natural resources. Looking in to the benefits the flora and fauna were rehabilitees in form of tissue culture, co preservation, plantation etc. for the availability in its natural form. Nature is the best chemist, which helps in combatting the aliments and provides the outcomes of it. It is impossible to find any plant, which has no medical use.
Ulcer and liver diseases are at an alarming rate in the developing countries. A number of drugs, which are in the existing medications for peptic ulcer and hepatic diseases, shows a comeback region due to its adverse effects, and drug interactions. Drugs, which consists from the flora, has its importance in the treatment and shows a higher rate of acceptance. Flavonoids are the naturally occurring, low molecular weight molecules seen mostly distributed in the vegetable kingdom and holds an utmost thurst in declining the generation of reactive oxygen species. Secondary compounds like apigenin, sylimarin, genesis, quercetin, kaempherol and catechins has a significance role in these diseases.
Holoptelea integrifolia (Ulmaceae) is a diversely used in Traditional Systems of medicine for healing aliments. The plant is preferred in the treatment and curing diseases like leprosy, inflammation, rickets, leucoderma, scabies, rheumatism, eczema, malaria and many more. The plants exhibits various pharmacological activities like antimicrobial, nociceptive, antiaging ,inflammation, anthelmintic, antidiabetic, adaptogenic, anticancer, wound healing, hepatoprotective, and hypolipidemic. The study on moprphological and microscopical was carried out on this plant as per the standards laid down by who to find the genuinity of the species. Physical constant values involving moisture content, ash and extractives as well as qualitative and quantitative estimation of various phytochemical have been studied. The presence of Saponins, Tannins, Terpenoids, Steroid, Flavonoids, and some other chemical constituents were recorded followed by antimicrobial activity of the plant against Gram Positive and Gram Negative Bacteria. Looking forward with the potential aspects of the plant used in Traditional system standardization parameters were to be considered for its validation and authentication.
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