Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

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Two new taxoids, taxumairol Q (1) and 13-O-acetyl wallifoliol (2), have been isolated from the leaves and twigs of Taxus sumatrana. Taxuspine F and wallifoliol (10) have been isolated for the first time from the yew T. sumatrana. Seventeen known taxoid diterpenoids have also been isolated. The new derivatives, 9,13-diacetyltaxumairol W (3), 10,13-dibenzoyltaxacustin (4), 7,13-diacetylwallifoliol (5), 7,13-dibenzoylwallifoliol (6), and 7,9-dibenzoyltaxumairol P (7), have been prepared by acylation of a crude mixture of taxoids. All structures were established primarily on the basis of 1D and 2D NMR techniques, including DEPT, COSY, and HMBC experiments, as well as chemical correlation with known compounds. Wallifoliol (10) exhibited significant cytotoxicities against both Hepa 59 T/VGH (human liver carcinoma) and KB (human oral epidermoid carcinoma) tumor cells. Taxuspine F and compound 5 possessed moderate activity against Hepa cells only, while 3, 6, 7, and 10-deacetylbaccatin III showed only marginal activity against Hepa cells.

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Today, the size of a multimedia file is increasing day by day from gigabytes to terabytes or even petabytes, mainly because of the evolution of a large amount of real-time data. As most of the multimedia files are transmitted through the internet, hackers and attackers try to access the users’ personal and confidential data without any authorization. Thus, maintaining a strong security technique has become a significant concerned to protect the personal information. Deoxyribonucleic Acid (DNA) computing is an advanced field for improving security, which is based on the biological concept of DNA. A novel DNA-based encryption scheme is proposed in this article for protecting multimedia files in the cloud computing environment. Here, a 1024-bit secret key is generated based on DNA computing and the user's attributes and password to encrypt any multimedia file. To generate the secret key, the decimal encoding rule, American Standard Code for Information Interchange value, DNA reference key, and complementary rule are used, which enable the system to protect the multimedia file against many security attacks. Experimental results, as well as theoretical analyses, show the efficiency of the proposed scheme over some well-known existing schemes.