New Taxane Diterpenoids from the Leaves and Twigs of <i>Taxus sumatrana</i>

Five new benzenoids, benzocamphorins A-E (1-5), and ten recently isolated triterpenoids, camphoratins A-J (16-25), together with 23 known compounds including seven benzenoids (6-12), three lignans (13-15), and 13 triterpenoids (26-38) were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis. Selected compounds were examined for cytotoxic and anti-inflammatory activities. Compounds 9 and 21 showed moderate cytotoxicity against MCF-7 and Hep2 cell lines with ED 50 values of 3.4 and 3.0 µg/mL, respectively. Compounds 21, 25, 26, 29-31, 33, and 36 demonstrated potent antiinflammatory activity by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC 50 values of 2.5, 1.6, 3.6, 0.6, 4.1, 4.2, 2.5, and 1.5 µM, respectively, which were better than those of the nonspecific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) (IC 50 : 25.8 µM). These results may substantiate the use of T. camphoratus in traditional Chinese medicine (TCM) for the treatment of inflammation and cancer-

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“…The assay procedure was carried out as previously described,26 and mitomycin was used as positive control.…”

Section: Methodsmentioning

confidence: 99%

Biologically active constituents from the fruiting body of Taiwanofungus camphoratus

Shi

Chao

Shen

et al. 2011

Bioorganic & Medicinal Chemistry

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“…The cytotoxic activities of compounds against KB (human mouth epidermoid carcinoma), DLD (human colon adenocarcinoma), NCI-H661 (human lung large cell carcinoma), Hepa (human hepatoma), and HepG2/A2 (human hepatoblastoma) cells were assayed by the MTT{3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide} colorimetric assay as previously described [23]. The cells for assay were cultured in RPMI-1640 medium supplemented with 5% CO 2 in an incubator at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents

et al. 2011

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A series of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-β-carboline analogs have been synthesized and evaluated for antitumor activity against human tumor cells including KB, DLD, NCI-H661, Hepa, and HepG2/A2 cell lines. Among these, compounds 2, 6, 7, and 9 exhibited the most potent and selective activity against the tested tumor cells. As for inhibition of topoisomerase II, compounds 1–14 and 18 showed better activity than etoposide. Among them, compounds 3, 4, 7, 9, and 10 exhibited potent activity. The structure and activity relationship (SAR) study revealed correlation between carbon numbers of the side chain and biological activities. The molecular complex with DNA for compound 2 was proposed.

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“…Pada T. sumatrana terdapat kandungan taxumairol Q, 13-O-acetyl wallifoliol (Shen et al 2002), dan tasumatrols E, F, dan G (Shen et al 2005), serta 10-deacetylbaccatin III dan baccatin III (Hidayat dan Tachibana 2013).…”

Section: Pendahuluanunclassified

Pola penyebaran dan potensi kerapatan Taxus sumatrana di Gunung Tujuh, Kabupaten Kerinci, Jambi

Frianto¹,

Novriyanti²

2016

Prosiding Seminar Nasional Masyarakat Biodiversitas Indonesia

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Abstrak. Frianto D, Novriyanti E. 2016. Pola penyebaran dan potensi kerapatan Taxus sumatrana di Gunung Tujuh, Kabupaten Kerinci,. Taxus sumatrana termasuk ke dalam genus Taxus, famili Taxaceae, dan subdivisi Gymnospermae. Taxus merupakan tanaman sumber paclitaxel (taxol) yang bersifat antikanker. Studi ini bertujuan untuk mengetahui pola penyebaran dan potensi kerapatan Taxus sumatrana di Gunung Tujuh, Kabupaten Kerinci, Provinsi Jambi. Penelitian dilaksanakan dengan metode jalur dan garis berpetak. Pengamatan dilakukan pada ketinggian 1.690-2.120 m dpl. Data pola penyebaran dianalisis dengan rumus indeks Morisita, sedangkan untuk mengetahui pola penyebaran secara berkelompok atau tidak dilakukan dengan distribusi Chi-square. Faktor abiotik yang diamati meliputi suhu tanah, pH tanah, dan intensitas cahaya. Hasil pengamatan menunjukkan bahwa pola penyebaran Taxus sumatrana di Gunung Tujuh berdasarkan indeks Morisita terjadi secara berkelompok (1,21). Sementara itu, hasil uji lanjut distribusi Chi-square (155,49) menunjukkan pola penyebaran yang tidak berbeda nyata dengan pola penyebaran berkelompok. Pada eksplorasi ini, Taxus sering ditemukan di daerah-daerah tebing tepi sungai. Potensi kerapatan Taxus sumatrana sekitar 10,19 pohon/ha. Faktor lingkungan yang diamati meliputi suhu tanah yaitu berkisar antara 20,9-23,5 o C, pH tanah sekitar 6,8, dan intensitas cahaya berkisar antara 257-639 Lux. Taxus is a source of paclitaxel (taxol), an anticancer substance. This study aimed to examine the distribution pattern and the density potential of T. sumatrana at Mount Tujuh, Kerinci District, Jambi Province. The research was conducted with a combination of transect and line compartment method. The observation was conducted at an elevation of 1.690-2.120 m asl. The collected data of distribution pattern were analyzed with Morisita Index. Further, the data was analyzed with Chi-square distribution to define grouped or ungrouped distribution pattern. Abiotic factors observed included soil temperature, soil pH, and light intensity. The results showed that the distribution pattern of T. sumatrana in Mount Tujuh based on Morisita Index was classified as grouped (1.21). Meanwhile, the results of further analysis of Chi-square distribution (155.49) showed the result that there was no significant difference with a grouped distribution pattern. In this study, Taxus was mostly found at ravine or cliff of river banks. Potential of the density of T. sumatrana was 10.19 trees/ha. The abiotic factors observed included soil temperature ranged between 20.9-23.5 o C, soil pH was about 6.8 and light intensity ranged between 257-639 Lux.Keywords: Mount Tujuh, distribution pattern, density potential, Taxus sumatrana PENDAHULUANTaxus sumatrana termasuk ke dalam famili Taxaceae dan subdivisi Gymnospermae. Di Indonesia, T. sumatrana dikenal dengan nama cemara sumatra. Taxus sumatrana tumbuh pada strata subkanopi di hutan pegunungan. Tempat tumbuh T. sumatrana umumnya terdapat di bagian punggung bukit, lereng-lereng terjal, dan tepian jurang (R...

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New Taxane Diterpenoids from the Leaves and Twigs of Taxus sumatrana

Cited by 39 publications

References 20 publications

Biologically active constituents from the fruiting body of Taiwanofungus camphoratus

Biologically active constituents from the fruiting body of Taiwanofungus camphoratus

Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents

Pola penyebaran dan potensi kerapatan Taxus sumatrana di Gunung Tujuh, Kabupaten Kerinci, Jambi

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