The relationship between pineal and thyroid in response to the adrenocortical modulation is poorly understood. In the present study post pubertal male rats were treated with natural and synthetic corticoids and an antiadrenal agent mitotane. Hydroxycortisone was administered at a dose of 4 mg / 100 g b.w., dexamethasone 2 mg / 100 g b.w. and mitotane 3 mg / 100 g b.w. for fifteen consecutive days. Our data revealed that both the corticoids, hydroxycorticosterone and dexamethasone induced hyperactivity of pineal and thyrofollicular cell morphology. The functional relation between the cells of the pineal parenchyma and thyroid follicles were noted. Similar results were induced by mitotane, an antiadrenal agent. It is concluded, that our present study indicates a mutual relationship between the pineal and the thyroid gland karyomorphological and functional parameters in response to corticoids and an antiadrenal agent in post pubertal male rat (Rattus rattus).
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