Stimulatory response of pineal-thyroid nuclear morphology and function following adrenocortical modulation in rat (Rattus rattus)

Abstract

The relationship between pineal and thyroid in response to the adrenocortical modulation is poorly understood. In the present study post pubertal male rats were treated with natural and synthetic corticoids and an antiadrenal agent mitotane. Hydroxycortisone was administered at a dose of 4 mg / 100 g b.w., dexamethasone 2 mg / 100 g b.w. and mitotane 3 mg / 100 g b.w. for fifteen consecutive days. Our data revealed that both the corticoids, hydroxycorticosterone and dexamethasone induced hyperactivity of pineal and thyrofollicular cell morphology. The functional relation between the cells of the pineal parenchyma and thyroid follicles were noted. Similar results were induced by mitotane, an antiadrenal agent. It is concluded, that our present study indicates a mutual relationship between the pineal and the thyroid gland karyomorphological and functional parameters in response to corticoids and an antiadrenal agent in post pubertal male rat (Rattus rattus).

Metyrapone, a corticoid inhibitor, induces inverse changes in pineal and adrenal karyomorphology, dynamics and function in mice (Mus musculus)

“…Thus alteration in the nuclear size reflects the nature of synthetic and secretory activity of both pineal gland (Quay, 1976;Diehl et al, 1984;Hira et al, 1989;Sinha et al, 2009;Bandopadhyay et al 2010) and adrenal cortex (Miller, 1954; in mammals.…”

“…In all cases pineal (Quay, 1976;Chakraborty, , 1993Chakraborty, , 1994Chakraborty and Maiti, 1981;Chakraborty et al, , 1982Chakraborty et al, , 1994Diehl et al, 1984;Hira et al, 1989;Bandopadhyay and Chakraborty, 2010;Sinha et al, 2009) and adrenal (Miller, 1954;Maitra and Chakraborty, 1983;Chakraborty, 1994; cytological studies were made from midsagittal paraffin sections of 5 µm thickness stained following haematoxylin-eosin and observed under oil immersion (15 ocular x 100 objective). Only the right adrenal glands were used for histological studies.…”

Hemicastration induced stimulation of pineal and adrenocortical karyomorphology and cell proliferation can be reversed by steroid hormone and antihormone modulations in mice (Mus musculus)

“…It is interesting to note that the cytophysiological changes indicated by karyomorphological alterations in the pineal gland (Quay, 1976;Chakraborty et al, 1981;Diehl et al, 1984;Sahu and Chakraborty, 1986;Hira et al, 1989;Sinha et al, 2009;Bandyopadhyay and Chakraborty, 2010) and adrenal cortex (Miller, 1954;Bandyopadhyay and Chakraborty, 2010) in mammals provide valuable indices of the nature of activities of these glands. Current experimental results show that hemicastration in postpubertal male mice causes pineal and adrenocortical stimulation at cytological level as indicated by increased karyometric values compared to control group of mice.…”

“…In all cases pineal (Quay, 1976;Chakraborty, 1981;1993, 1994Chakraborty and Maiti, 1981;Chakraborty et al, 1981Chakraborty et al, , 1994Maiti and Chakraborty, 1982;Diehl et al, 1984;Sahu and Chakraborty, 1986;Chaudhuri and Maiti, 1989;Hira et al, 1989;Bandyopadhyay et al, 2000;Sinha et al, 2009;Bandyopadhyay and Chakraborty, 2010) and adrenal (Miller, 1954;Maitra and Chakraborty, 1983;Chakraborty, 1994;Bandyopadhyay and Chakraborty, 2010) cytological studies were made from midsagittal paraffin section of 5 µm thickness stained following haematoxylin-eosin and observed under oil immersion (15 ocular x 100 objective). The pineal gland section and only the right adrenal gland sections were used for histological studies.…”