Objective: To evaluate the clinical efficacy of TCM therapy for elevating Yang in the treatment of posterior circulation ischemic vertigo. Methods: all clinical randomized controlled trials of therapy for elevating Yang's posterior circulation ischemic vertigo were screened by computer searching Chinese databases such as CNKI, Wanfang database, VIP Chinese science and technology and the Cochrane Library, PubMed, EMBASE and other English databases from the time the library was built to October 2020, and relevant references were manually reviewed. Patients in the control group were treated with western medicine, while those in the experimental group were treated with either Elevating Yang recipe (decoction) or Elevating Yang recipe (decoction) combined with western medicine. The Review Manager 5.3 software was used to conduct a meta-analysis on the clinical effective rate, TCM syndrome scores, vertebrobasilar blood flow velocity, and adverse reactions. Results: Eleven articles were finally included, covering a total of 1049 patients, including 522 cases in the observation group and 527 cases in the control group. The clinical effective rate of patients in the experimental group is higher than that in the control group [RR=1.22(1.16,1.28)], the vertebral-basilar artery blood flow velocity in the experimental group includes left vertebral artery (LVA) [
Nanosealing technology has become the key to overcoming the wellbore instability problem in deep and ultradeep shale formations. In this Article, the terpolymer poly(MM-EM-BM) was synthesized from methyl methacrylate, ethyl methacrylate, and butyl methacrylate by a Michael addition reaction. The poly(MM-EM-BM) nanoparticles were investigated by Fourier transform infrared spectroscopy, laser scattering analysis, and thermogravimetric analysis. The results imply that the particle size range of poly(MM-EM-BM) is between 33.90 and 135.62 nm and the average diameter is about 85.95 nm at room temperature, which can maintain excellent stability at 382.75 °C. The effects of poly(MM-EM-BM) on the properties of oil-based drilling fluids (OBDFs) were ascertained through experiments on the rheological performance, electrical stability, and high-temperature and high-pressure (HTHP) filtration loss. The results suggested that when the amount of added poly(MM-EM-BM) increases, the apparent viscosity, plastic viscosity, dynamic shear force, and demulsification voltage of the drilling fluids will increase correspondingly; in contrast, the HTHP filtration loss gradually decreased. When poly(MM-EM-BM) is added at 0.75%, the kinetic-to-plastic ratio of the drilling fluids is 0.24 and the filtration loss is 0.6 mL, showing excellent overall performance. The drilling fluids have a good rock-carrying ability and water loss wall-building property. The sealing performance and mechanism of poly(MM-EM-BM) were researched by the method of a sealing performance test under high temperature. The results indicated that the more poly(MM-EM-BM) used, the higher the sealing efficiency of the mud cake and the core as the sealing medium. When poly(MM-EM-BM) was added at 0.75%, the sealing rates of the mud cake and the core as the sealing medium reached the maximum sealing rates of 40.30% and 91.48%, respectively. When poly(MM-EM-BM) enters the core nanopore joint for a certain distance under formation pressure, a tight sealing layer will be formed to effectively prevent the entry of filtrate. Poly(MM-EM-BM) as a potential oil-based nanosealing agent is expected to solve the problem caused by wellbore instability in shale horizontal wells.
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