Background The full range of long-term health consequences of COVID-19 in patients who are discharged from hospital is largely unclear. The aim of our study was to comprehensively compare consequences between 6 months and 12 months after symptom onset among hospital survivors with COVID-19. MethodsWe undertook an ambidirectional cohort study of COVID-19 survivors who had been discharged from Jin Yin-tan Hospital (Wuhan, China) between Jan 7 and May 29, 2020. At 6-month and 12-month follow-up visit, survivors were interviewed with questionnaires on symptoms and health-related quality of life (HRQoL), and received a physical examination, a 6-min walking test, and laboratory tests. They were required to report their health-care use after discharge and work status at the 12-month visit. Survivors who had completed pulmonary function tests or had lung radiographic abnormality at 6 months were given the corresponding tests at 12 months. Non-COVID-19 participants (controls) matched for age, sex, and comorbidities were interviewed and completed questionnaires to assess prevalent symptoms and HRQoL. The primary outcomes were symptoms, modified British Medical Research Council (mMRC) score, HRQoL, and distance walked in 6 min (6MWD). Multivariable adjusted logistic regression models were used to evaluate the risk factors of 12-month outcomes. Findings 1276 COVID-19 survivors completed both visits. The median age of patients was 59•0 years (IQR 49•0-67•0) and 681 (53%) were men. The median follow-up time was 185•0 days (IQR 175•0-198•0) for the 6-month visit and 349•0 days (337•0-361•0) for the 12-month visit after symptom onset. The proportion of patients with at least one sequelae symptom decreased from 68% (831/1227) at 6 months to 49% (620/1272) at 12 months (p<0•0001). The proportion of patients with dyspnoea, characterised by mMRC score of 1 or more, slightly increased from 26% (313/1185) at 6-month visit to 30% (380/1271) at 12-month visit (p=0•014). Additionally, more patients had anxiety or depression at 12-month visit (26% [331/1271] at 12-month visit vs 23% [274/1187] at 6-month visit; p=0•015). No significant difference on 6MWD was observed between 6 months and 12 months. 88% (422/479) of patients who were employed before COVID-19 had returned to their original work at 12 months. Compared with men, women had an odds ratio of 1•43 (95% CI 1•04-1•96) for fatigue or muscle weakness, 2•00 (1•48-2•69) for anxiety or depression, and 2•97 (1•50-5•88) for diffusion impairment. Matched COVID-19 survivors at 12 months had more problems with mobility, pain or discomfort, and anxiety or depression, and had more prevalent symptoms than did controls.Interpretation Most COVID-19 survivors had a good physical and functional recovery during 1-year follow-up, and had returned to their original work and life. The health status in our cohort of COVID-19 survivors at 12 months was still lower than that in the control population.

The oceanic crust is formed by a combination of magmatic and tectonic processes at mid-ocean spreading centers. Under ultraslow spreading environment, however, observations of thin crust and mantle-derived peridotites on the seafloor suggest that a large portion of crust is formed mainly by tectonic processes, with little or absence of magmatism. Using three-dimensional seismic tomography at an ultraslow spreading Southwest Indian Ridge segment containing a central volcano at 50°28′E, here we report the presence of an extremely magmatic accretion of the oceanic crust. Our results reveal a low-velocity anomaly (À0.6 km/s) in the lower crust beneath the central volcano, suggesting the presence of partial melt, which is accompanied by an unusually thick crust (~9.5 km). We also observe a strong along-axis variation in crustal thickness from 9.5 to 4 km within 30-50 km distance, requiring a highly focused melt delivery from the mantle. We conclude that the extremely magmatic accretion is due to localized melt flow toward the central volcano, which was enhanced by the significant along-axis variation in lithosphere thickness at the ultraslow spreading Southwest Indian Ridge.

P-wave and S-wave receiver function analyses have been performed along a profile consisted of 27 broadband seismic stations to image the crustal and upper mantle discontinuities across Northeast China. The results show that the average Moho depth varies from about 37 km beneath the Daxing'anling orogenic belt in the west to about 33 km beneath the Songliao Basin, and to about 35 km beneath the Changbai mountain region in the east. Our results reveal that the Moho is generally flat beneath the Daxing'anling region and a remarkable Moho offset (about 4 km) exists beneath the basin-mountain boundary, the Daxing'anling-Taihang Gravity Line. Beneath the Tanlu faults zone, which seperates the Songliao Basin and Changbai region, the Moho is uplift and the crustal thickness changes rapidly. We interpret this feature as that the Tanlu faults might deeply penetrate into the upper mantle, and facilitate the mantle upwelling along the faults during the Cenozoic era. The average depth of the lithosphereasthenosphere boundary (LAB) is *80 km along the profile which is thinner than an average thickness of a continental lithosphere. The LAB shows an arc-like shape in the basin, with the shallowest part approximately beneath the center of the basin. The uplift LAB beneath the basin might be related to the extensive lithospheric stretching in the Mesozoic. In the mantle transition zone, a structurally complicated 660 km discontinuity with a maximum 35 km depression beneath the Changbai region is observed. The 35 km depression is roughly coincident with the location of the stagnant western pacific slab on top of the 660 km discontinuity revealed by the recent P wave tomography.

Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis.